White spot syndrome virus (WSSV) causes severe disease in crustaceans, specifically shrimp, leading to substantial economic losses to the aquaculture industry. Existing treatment methods fail to sufficiently curb the occurrence and spread of the disease, necessitating the development of effective control and treatment strategies. Structural studies have primarily focused on envelope proteins and a few non-structural proteins involved in host entry, viral replication, viral assembly and host immune evasion, thus presenting themselves as potential drug targets. Here, we provide a comprehensive review of the insights gained from such structural elucidations to contribute to developing novel therapeutic strategies. In addition, we touch upon the current and future perspectives towards structure-based drug or vaccine development against WSSV.

中文翻译：

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白斑综合征病毒蛋白质的结构洞察：基于结构的抗病毒策略的观点

白斑综合症病毒 (WSSV) 在甲壳类动物，特别是对虾中引起严重疾病，给水产养殖业带来巨大的经济损失。现有的治疗方法未能充分遏制疾病的发生和传播，需要制定有效的控制和治疗策略。结构研究主要集中在包膜蛋白和一些参与宿主进入、病毒复制、病毒组装和宿主免疫逃逸的非结构蛋白，因此它们本身就是潜在的药物靶点。在这里，我们全面回顾了从这些结构阐明中获得的见解，以有助于开发新的治疗策略。此外，我们还谈到了针对 WSSV 的基于结构的药物或疫苗开发的当前和未来前景。