Background

Outbreaks of airborne viral infections, such as COVID-19, can cause panic regarding other severe respiratory syndrome diseases that may develop and affect public health. It is therefore necessary to develop control methods that offer protection against such viruses.

Aim of Review

To identify a feasible solution for virus deactivation, we critically reviewed methods of generating reactive oxygen species (ROS), which can attack a wide range of molecular targets to induce antiviral activity, accounting for their flexibility in facilitating host defense mechanisms against a comprehensive range of pathogens. Recently, the role of ROS in microbial decontamination has been critically investigated as a major topic in infectious diseases. ROS can eradicate pathogens directly by inducing oxidative stress or indirectly by promoting pathogen removal through numerous non-oxidative mechanisms, including autophagy, T-cell responses, and pattern recognition receptor signaling.

Key scientific concepts of review

In this article, we reviewed possible methods for the in vitro generation of ROS with antiviral activity. Furthermore, we discuss, in detail, the novel and environmentally friendly cold plasma delivery system in the destruction of viruses. This review highlights the potential of ROS as therapeutic mediators to modernize current techniques and improvement on the efficiency of inactivating SARS-CoV2 and other viruses.

中文翻译：

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通过物理和冷大气等离子体技术产生的活性氧对病毒的灭活和破坏：现状和前景

背景

空气传播的病毒感染（例如 COVID-19）的爆发可能会引起人们对可能发展并影响公众健康的其他严重呼吸系统综合症疾病的恐慌。因此有必要开发提供针对此类病毒的保护的控制方法。

审查目的

为了确定病毒灭活的可行解决方案，我们批判性地审查了产生活性氧 (ROS) 的方法，这些方法可以攻击范围广泛的分子靶标以诱导抗病毒活性，并解释了它们在促进宿主防御机制以抵抗多种病毒的灵活性方面的原因。病原体。最近，ROS 在微生物净化中的作用已作为传染病的主要课题进行了批判性研究。ROS 可以通过诱导氧化应激直接根除病原体，或通过多种非氧化机制（包括自噬、T 细胞反应和模式识别受体信号转导）促进病原体清除来间接根除病原体。

综述的关键科学概念

在这篇文章中，我们回顾了体外产生具有抗病毒活性的 ROS的可能方法。此外，我们详细讨论了新型环保的冷等离子体输送系统在病毒破坏中的作用。这篇综述强调了 ROS 作为治疗介质使当前技术现代化并提高 SARS-CoV2 和其他病毒灭活效率的潜力。