RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than that used by transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.

中文翻译：

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NDF 是一种通过 RNA 聚合酶 II 刺激延伸的转录因子

RNA 聚合酶 II (Pol II) 延伸是基因表达的关键步骤。在这里，我们发现被鉴定为双侧核小体不稳定因子的 NDF 也是一种 Pol II 转录因子，可在没有核小体的情况下用普通 DNA 模板刺激延伸。NDF 直接与 Pol II 结合并通过与转录因子 TFIIS 使用的机制不同的机制来增强延伸。此外，与 NDF 相关的酵母 Pdp3 与 Pol II 结合并刺激伸长。因此，NDF 是一种 Pol II 结合转录延伸因子，位于基因体上，从酵母到人类都是保守的。