Coronavirus disease 2019 (COVID-19) has disproportionately affected people with mental health conditions.

We investigated the association between receiving psychotropic drugs, as an indicator of mental health conditions, and COVID-19 vaccine uptake.

We conducted a cross-sectional analysis of a prospective cohort of the Northern Ireland adult population using national linked primary care registration, vaccination, secondary care and pharmacy dispensing data. Univariable and multivariable logistic regression analyses investigated the association between anxiolytic, antidepressant, antipsychotic, and hypnotic use and COVID-19 vaccination status, accounting for age, gender, deprivation and comorbidities. Receiving any COVID-19 vaccine was the primary outcome.

There were 1 433 814 individuals, of whom 1 166 917 received a COVID-19 vaccination. Psychotropic medications were dispensed to 267 049 people. In univariable analysis, people who received any psychotropic medication had greater odds of receiving COVID-19 vaccination: odds ratio (OR) = 1.42 (95% CI 1.41–1.44). However, after adjustment, psychotropic medication use was associated with reduced odds of vaccination (ORadj = 0.90, 95% CI 0.89–0.91). People who received anxiolytics (ORadj = 0.63, 95% CI 0.61–0.65), antipsychotics (ORadj = 0.75, 95% CI 0.73–0.78) and hypnotics (ORadj = 0.90, 95% CI 0.87–0.93) had reduced odds of being vaccinated. Antidepressant use was not associated with vaccination (ORadj = 1.02, 95% CI 1.00–1.03).

We found significantly lower odds of vaccination in people who were receiving treatment with anxiolytic and antipsychotic medications. There is an urgent need for evidence-based, tailored vaccine support for people with mental health conditions.

2019 年冠状病毒病 (COVID-19) 对有心理健康问题的人的影响尤为严重。

我们调查了接受精神药物（作为心理健康状况的指标）与 COVID-19 疫苗接种之间的关联。

我们使用全国关联的初级保健登记、疫苗接种、二级保健和药房配药数据，对北爱尔兰成年人口的前瞻性队列进行了横断面分析。单变量和多变量逻辑回归分析调查了抗焦虑药、抗抑郁药、抗精神病药和催眠药的使用与 COVID-19 疫苗接种状态之间的关联，并考虑了年龄、性别、剥夺和合并症。接受任何 COVID-19 疫苗是主要结果。

共有 1 433 814 人，其中 1 166 917 人接种了 COVID-19 疫苗。向 267 049 人分发了精神药物。在单变量分析中，接受任何精神药物治疗的人接受 COVID-19 疫苗接种的几率更高：优势比 (OR) = 1.42 (95% CI 1.41–1.44)。然而，调整后，精神药物的使用与疫苗接种几率降低相关（OR adj = 0.90，95% CI 0.89–0.91）。接受抗焦虑药（OR adj = 0.63，95% CI 0.61-0.65）、抗精神病药（OR adj = 0.75，95% CI 0.73-0.78）和安眠药（OR adj = 0.90，95% CI 0.87-0.93）的人几率降低接种疫苗。抗抑郁药的使用与疫苗接种无关（OR adj= 1.02，95% CI 1.00–1.03）。

我们发现接受抗焦虑和抗精神病药物治疗的人接种疫苗的几率明显较低。迫切需要为有心理健康问题的人提供基于证据的、量身定制的疫苗支持。