The coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 is usually a mild condition; however, in some cases it can result in severe sickness and even death. Thus, understanding the reasons behind these grave outcomes is of great importance. Coronavirus disease 2019 and periodontitis share some intriguing characteristics. They can both lead to systemic inflammation and alterations of coagulation pathways, and both share confounding factors, such as diabetes, hypertension, and obesity. Accordingly, a possible association between these conditions has been hypothesized in the literature. The objective of this review was to evaluate the scientific evidence linking these diseases and the possible underlying mechanisms. Evidence has shown that coronavirus disease 2019 presents oral manifestations and can even affect periodontal tissues. Moreover, some studies have shown a possible association between coronavirus disease 2019 severity and the presence of periodontitis. Current evidence suggests that this association could be explained through the direct role of periodontal bacteria in aggravating lung infections, as well as through the indirect effect of periodontitis in inducing systemic inflammation and priming of the immune system to an exacerbated reaction to severe acute respiratory syndrome coronavirus 2 infection. Future research is needed to confirm these observations and explore the possible role that periodontal care might play in the coronavirus disease 2019 pandemic.

中文翻译：

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牙周炎和冠状病毒病 2019


由严重急性呼吸综合征冠状病毒 2 型引起的 2019 年冠状病毒病通常病情较轻；然而，在某些情况下，它可能会导致严重的疾病甚至死亡。因此，了解这些严重后果背后的原因非常重要。 2019 年冠状病毒病和牙周炎有一些有趣的特征。它们都会导致全身炎症和凝血途径的改变，并且都有共同的混杂因素，例如糖尿病、高血压和肥胖。因此，文献中假设了这些条件之间可能存在关联。本次综述的目的是评估将这些疾病与可能的潜在机制联系起来的科学证据。有证据表明，2019冠状病毒病会出现口腔症状，甚至会影响牙周组织。此外，一些研究表明 2019 年冠状病毒病的严重程度与牙周炎之间可能存在关联。目前的证据表明，这种关联可以通过牙周细菌在加重肺部感染中的直接作用，以及牙周炎在诱发全身炎症和启动免疫系统对严重急性呼吸综合征冠状病毒的加剧反应中的间接作用来解释。 2感染。需要未来的研究来证实这些观察结果，并探索牙周护理在 2019 年冠状病毒病大流行中可能发挥的作用。