Background. This study sought to explore the association between quantitative classification of renal surface nodularity (qRSN) based on computed tomography (CT) imaging and early renal injury (ERI) in patients with arterial hypertension. Methods. A total of 143 patients with a history of hypertension were retrospectively enrolled; clinical information (age, sex, hypertension grade, and hypertension course), laboratory tests, and qRSN were collected or assessed. The subjects were divided into an ERI group (n = 60) or a control group (CP, n = 83) according to ERI diagnosis based on the following criteria: cystatin C > 1.02 mg/L. Univariate analysis and multiple logistic regression were used to assess the association between ERI and qRSN. A receiver operating characteristic curve (ROC) was performed to compare multiple logistic regression models with or without qRSN for differentiating the ERI group from the control group. Results. In univariate analysis, hypertension grade, hypertension course, triglycerides (TG), and qRSN were related to ERI in patients with arterial hypertension (all ), with strong interrater agreement of qRSN. Multiple logistic regression analysis showed an area under the ROC curve of 0.697 in the model without qRSN and 0.790 in the model with qRSN, which was significantly different (Z = 2.314, ). Conclusion. CT imaging-based qRSN was associated with ERI in patients with arterial hypertension and may be an imaging biomarker of early renal injury.

中文翻译：

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动脉高血压患者肾表面结节定量分类与早期肾损伤的关系

背景。本研究旨在探讨基于计算机断层扫描 (CT) 成像的肾表面结节 (qRSN) 定量分类与动脉高血压患者早期肾损伤 (ERI) 之间的关联。方法。回顾性纳入143例有高血压病史的患者；收集或评估临床信息（年龄、性别、高血压等级和高血压病程）、实验室检查和 qRSN。受试者被分为 ERI 组 ( n  = 60) 或对照组 (CP, n = 83) 根据基于以下标准的 ERI 诊断：胱抑素 C > 1.02 mg/L。单变量分析和多元逻辑回归用于评估 ERI 和 qRSN 之间的关联。进行受试者工作特征曲线 (ROC) 以比较使用或不使用 qRSN 的多个逻辑回归模型，以区分 ERI 组与对照组。结果。在单因素分析中，高血压分级、高血压病程、甘油三酯（TG）和 qRSN 与动脉高血压患者的 ERI 相关（所有)，具有强的 qRSN 评价者协议。多元逻辑回归分析显示，无 qRSN 模型的 ROC 曲线下面积为 0.697，有 qRSN 模型的 ROC 曲线下面积为 0.790，差异显着（ Z  = 2.314，）。 结论。基于 CT 成像的 qRSN 与动脉高血压患者的 ERI 相关，可能是早期肾损伤的成像生物标志物。