The nosographic structure of posttraumatic stress disorder (PTSD) remains unclear, and attempts to determine its symptomatic organization have been unsatisfactory. Several explanations have been suggested, and the impact of trauma type is receiving increasing attention. As little is known about the differential impact trauma type in the nosographic structure of PTSD, we explored the nosology of PTSD and the effect of trauma type on its symptomatic organization. We reanalyzed five cross-sectional psychopathological networks involving different trauma types, encompassing a broad range of traumatic events in veterans, war-related trauma in veterans, sexual abuse, terrorist attacks, and various traumatic events in refugees. The weighted topological overlap was used to estimate the networks and attribute weights to their links. Coexpression differential network analysis was used to identify the common and specific network structures of the connections across different trauma types and to determine the importance of symptoms across the networks. We found a set of symptoms with more common connections with other symptoms, suggesting that these might constitute the prototypical nosographic structure of PTSD. We also found a set of symptoms that had a high number of specific connections with other symptoms; these connections varied according to trauma type. The importance of symptoms across the common and specific networks was ascertained. The present findings offer new insights into the symptomatic organization of PTSD and support previous research on the impact of trauma type on the nosology of this disorder.

中文翻译：

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跨创伤类型的创伤后应激症状的 nosographic 结构：探索性网络分析方法

创伤后应激障碍 (PTSD) 的 nosographic 结构仍不清楚，并且试图确定其症状组织的尝试并不令人满意。已经提出了几种解释，创伤类型的影响正受到越来越多的关注。由于对 PTSD 疾病谱结构中的不同影响创伤类型知之甚少，我们探讨了 PTSD 的疾病学以及创伤类型对其症状组织的影响。我们重新分析了五个涉及不同创伤类型的横断面精神病理学网络，包括退伍军人的广泛创伤事件、退伍军人与战争相关的创伤、性虐待、恐怖袭击和难民的各种创伤事件。加权拓扑重叠用于估计网络并将权重分配给它们的链接。共表达差异网络分析用于识别不同创伤类型之间连接的共同和特定网络结构，并确定症状在网络中的重要性。我们发现了一组与其他症状有更常见联系的症状，这表明这些可能构成了 PTSD 的典型 nosographic 结构。我们还发现了一组与其他症状有大量特定联系的症状；这些联系因创伤类型而异。确定了症状在常见和特定网络中的重要性。目前的研究结果为创伤后应激障碍的症状组织提供了新的见解，并支持了先前关于创伤类型对该疾病疾病分类学影响的研究。