The link between oral health and adverse pregnancy outcomes has been suggested by numerous epidemiological studies. More recent studies indicate the relationship between severity of periodontal disease and adverse pregnancy outcomes. Two virulence mechanisms are proposed: direct invasion of oral microorganisms or their components into the fetal-placenta unit and inflammatory mediators produced in the oral cavity affecting the fetal-placenta unit. While interventional periodontal therapy still yielded contradictory results, animal studies suggest that maternal supplementation of omega-3 fatty acids protects the fetus by suppressing inflammation as well as bacteria proliferation in the placenta. This article reviews the recent epidemiological, mechanistic, interventional, and therapeutic studies of oral health and adverse pregnancy outcomes.

中文翻译：

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口腔细菌、口腔健康和不良妊娠结局

大量流行病学研究表明口腔健康与不良妊娠结局之间存在联系。最近的研究表明牙周病的严重程度与不良妊娠结局之间的关系。提出了两种毒力机制：口腔微生物或其成分直接侵入胎儿胎盘单位和口腔中产生的影响胎儿胎盘单位的炎症介质。虽然介入性牙周治疗仍然产生了矛盾的结果，但动物研究表明，母体补充 omega-3 脂肪酸可以通过抑制炎症和胎盘细菌增殖来保护胎儿。本文回顾了最近关于口腔健康和不良妊娠结局的流行病学、机制、介入和治疗研究。