Metabolomics is an area of intriguing and growing interest. Since the late 1990s, when the first Omic applications appeared to study metabolite's pool (“metabolome”), to understand new aspects of the global regulation of cellular metabolism in biology, there have been many evolutions. Currently, there are many applications in different fields such as clinical, medical, agricultural, and food. In our opinion, it is clear that developments in metabolomics analysis have also been driven by advances in mass spectrometry (MS) technology. As natural complex products (NCPs) are increasingly used around the world as medicines, food supplements, and substance-based medical devices, their analysis using metabolomic approaches will help to bring more and more rigor to scientific studies and industrial production monitoring. This review is intended to emphasize the importance of metabolomics as a powerful tool for studying NCPs, by which significant advantages can be obtained in terms of elucidation of their composition, biological effects, and quality control. The different approaches of metabolomic analysis, the main and basic techniques of multivariate statistical analysis are also briefly illustrated, to allow an overview of the workflow associated with the metabolomic studies of NCPs. Therefore, various articles and reviews are illustrated and commented as examples of the application of MS-based metabolomics to NCPs.

中文翻译：

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基于质谱的代谢组学分析作为天然复杂产品质量控制的工具

代谢组学是一个引人入胜且兴趣日益浓厚的领域。自 1990 年代后期，当第一个 Omic 应用程序出现以研究代谢物池（“代谢组”）以了解生物学中细胞代谢的全球调节的新方面时，出现了许多演变。目前，在临床、医疗、农业、食品等不同领域都有很多应用。我们认为，代谢组学分析的发展显然也受到质谱 (MS) 技术进步的推动。随着天然复合物产品 (NCP) 在世界范围内越来越多地用作药物、食品补充剂和基于物质的医疗器械，使用代谢组学方法对其进行分析将有助于为科学研究和工业生产监测带来越来越严格的要求。本综述旨在强调代谢组学作为研究 NCPs 的有力工具的重要性，通过它可以在阐明其组成、生物学效应和质量控制方面获得显着优势。还简要说明了代谢组学分析的不同方法、多变量统计分析的主要和基本技术，以概述与 NCPs 代谢组学研究相关的工作流程。因此，各种文章和评论作为基于 MS 的代谢组学应用于 NCP 的示例进行了说明和评论。还简要说明了代谢组学分析的不同方法、多变量统计分析的主要和基本技术，以概述与 NCPs 代谢组学研究相关的工作流程。因此，各种文章和评论作为基于 MS 的代谢组学应用于 NCP 的示例进行了说明和评论。还简要说明了代谢组学分析的不同方法、多变量统计分析的主要和基本技术，以概述与 NCPs 代谢组学研究相关的工作流程。因此，各种文章和评论作为基于 MS 的代谢组学应用于 NCP 的示例进行了说明和评论。