Senescence is a cellular response to a variety of stress signals that is characterized by a stable withdrawal from the cell cycle and major changes in cell morphology and physiology. While most research on senescence has been performed on non-cancer cells, it is evident that cancer cells can also mount a senescence response. In this Review, we discuss how senescence can be induced in cancer cells. We describe the distinctive features of senescent cancer cells and how these changes in cellular physiology might be exploited for the selective eradication of these cells (senolysis). We discuss activation of the host immune system as a particularly attractive way to clear senescent cancer cells. Finally, we consider the challenges and opportunities provided by a ‘one-two punch’ sequential treatment of cancer with pro-senescence therapy followed by senolytic therapy.

衰老是细胞对各种应激信号的反应，其特征是细胞周期稳定退出，细胞形态和生理发生重大变化。虽然大多数关于衰老的研究都是在非癌细胞上进行的，但很明显，癌细胞也可以产生衰老反应。在这篇综述中，我们讨论了如何在癌细胞中诱导衰老。我们描述了衰老癌细胞的显着特征，以及如何利用细胞生理学的这些变化来选择性根除这些细胞（衰老溶解）。我们将宿主免疫系统的激活作为一种特别有吸引力的清除衰老癌细胞的方法进行讨论。最后，