A growing body of evidence suggests that intrapancreatic fat is associated with diabetes, but whether distribution of intrapancreatic fat across the regions of the pancreas has a pathophysiologic role is unknown. The aim of this study was to investigate the differences in intrapancreatic fat deposition between the head, body, and tail of the pancreas, as well as the relationship between regional intrapancreatic fat deposition and diabetes status and insulin traits. A total of 368 adults from the general population underwent MRI on a 3 Tesla scanner, and intrapancreatic fat was manually quantified in duplicate. Statistical models included adjustment for age, sex, ethnicity, BMI, and liver fat. Intrapancreatic fat deposition in the head, body, and tail of the pancreas did not differ significantly in adjusted models in either the overall cohort or the three subgroups based on diabetes status. HOMA of insulin resistance and fasting insulin were significantly positively associated with fat in the tail and body of the pancreas. There was no significant association between regional intrapancreatic fat and HOMA of β-cell function. The association of increased intrapancreatic fat deposition in the tail and body regions with increased insulin resistance may have an important role in the early identification of patients at risk for developing insulin resistance and diseases that stem from it.

中文翻译：

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根据糖尿病状态和胰岛素特性的胰腺内脂肪分布

越来越多的证据表明，胰腺内脂肪与糖尿病有关，但胰腺内脂肪在整个胰腺区域的分布是否具有病理生理作用尚不清楚。本研究旨在探讨胰头、胰体和胰尾之间的胰内脂肪沉积差异，以及区域胰内脂肪沉积与糖尿病状态和胰岛素性状之间的关系。共有 368 名来自普通人群的成年人在 3 特斯拉扫描仪上接受了 MRI，并一式两份手动量化了胰内脂肪。统计模型包括对年龄、性别、种族、BMI 和肝脏脂肪的调整。胰内脂肪沉积在头部、身体、在整个队列或基于糖尿病状态的三个亚组的调整模型中，胰尾和胰尾没有显着差异。胰岛素抵抗的HOMA和空腹胰岛素与胰尾和胰体脂肪显着正相关。区域胰腺内脂肪与β细胞功能HOMA之间无显着相关性。尾部和身体区域胰腺内脂肪沉积增加与胰岛素抵抗增加之间的关联可能在早期识别有发生胰岛素抵抗风险的患者和由此引起的疾病方面发挥重要作用。区域胰腺内脂肪与β细胞功能HOMA之间无显着相关性。尾部和身体区域胰腺内脂肪沉积增加与胰岛素抵抗增加之间的关联可能在早期识别有发生胰岛素抵抗风险的患者和由此引起的疾病方面发挥重要作用。区域胰腺内脂肪与β细胞功能HOMA之间无显着相关性。尾部和身体区域胰腺内脂肪沉积增加与胰岛素抵抗增加之间的关联可能在早期识别有发生胰岛素抵抗风险的患者和由此引起的疾病方面发挥重要作用。