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Epidemic-Like Calcium Signaling in Mobile Molecular Communication Networks
IEEE Transactions on NanoBioscience ( IF 3.7 ) Pub Date : 2022-02-28 , DOI: 10.1109/tnb.2022.3155644
Peng He 1 , Mengnan Su 1 , Yaping Cui 1 , Dapeng Wu 1 , Ruyan Wang 1
Affiliation  

Molecular Communication is an emerging technology enabling communications in nano-networks. Ca2+ signal is one promising option of MC due to the important role in bio-metabolisms and the available characteristics in communication engineering. So far, scientists analyze Ca2+ signaling via bio-experiments and simulations. Current researches lack a mathematical model for quantitative analysis of Ca2+ signal propagation on the network scale. In this work, we investigate the propagation patterns of Ca2+ signals in bio-cellular network. Firstly, we propose an improved Ca2+ dynamics model to describe Ca2+ signals considering movements of cells and attenuation of Ca2+ concentration. Then, we perform multi-modal analysis through the waveform characteristics, and classify cells according to their states. Moreover, a mathematical model is put forward to analyze the propagation of calcium signals based on typical epidemic model. The proposed model fully considers the similarity between: 1) epidemic disease propagates among mobile individuals; 2) Ca2+ signal propagates among mobile cells. The proposed model is amended to fit the case considering unique characters of Ca2+ signal. Finally, simulation results show that the proposed Ca2+ propagation model is coincident with Monte Carlo simulation results, indicating that the model is helpful for understanding how far and how fast Ca2+ signal can propagate.

中文翻译:


移动分子通信网络中类似流行病的钙信号传导



分子通信是一种能够在纳米网络中进行通信的新兴技术。由于在生物代谢中的重要作用以及在通信工程中的可用特性,Ca2+信号是 MC 的一种有前途的选择。到目前为止,科学家们通过生物实验和模拟来分析 Ca2+ 信号传导。目前的研究缺乏定量分析网络尺度上Ca2+信号传播的数学模型。在这项工作中,我们研究了生物细胞网络中 Ca2+ 信号的传播模式。首先,我们提出了一种改进的 Ca2+ 动力学模型来描述考虑细胞运动和 Ca2+ 浓度衰减的 Ca2+ 信号。然后,我们通过波形特征进行多模态分析,并根据细胞的状态对细胞进行分类。此外,基于典型的流行病模型,提出了分析钙信号传播的数学模型。所提出的模型充分考虑了以下方面的相似性:1)流行病在流动个体之间传播; 2) Ca2+信号在移动细胞之间传播。考虑到 Ca2+ 信号的独特特征,对所提出的模型进行了修改以适应情况。最后,仿真结果表明,所提出的Ca2+传播模型与蒙特卡罗仿真结果一致,表明该模型有助于了解Ca2+信号的传播距离和速度。
更新日期:2022-02-28
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