Canadian Journal of Fisheries and Aquatic Sciences, Ahead of Print.
Experiments examining potential impacts of growth hormone (GH) transgenesis in fish typically use a single source strain and do not address potential differential impacts in strains of different genetic backgrounds. Here, we examine the effects of differing genetic backgrounds when reared in culture on the growth of transgenic and nontransgenic coho salmon (Oncorhynchus kisutch) produced by mating sires from different rivers with transgenic dams from a single origin. We found a significant difference in size between offspring of sires originating from various river systems in British Columbia. This difference was independent of differences between transgenotypes (i.e., transgenic vs. nontransgenic offspring). However, the effects of strain or sire were relatively small compared to the effects of the transgene, which were consistent regardless of sire origin. Thus, results derived from studies of GH transgenic fish from a single source population can provide useful information for assessments of GH transgenic salmon from other systems. This has important implications for examining potential risks from introgression of a transgene into different populations.

中文翻译：

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评估野生遗传背景和亲本对生长激素转基因银鲑大小的影响

加拿大渔业和水生科学杂志，印刷前。
检查鱼中生长激素 (GH) 转基因的潜在影响的实验通常使用单一来源菌株，并且不解决不同遗传背景菌株的潜在差异影响。在这里，我们研究了在培养中饲养时不同遗传背景对转基因和非转基因银鲑（Oncorhynchus kisutch）生长的影响，这些鲑鱼由来自不同河流的公牛与来自单一来源的转基因大坝交配而产生。我们发现来自不列颠哥伦比亚省不同河流系统的公牛后代在大小上存在显着差异。这种差异与转基因型（即转基因与非转基因后代）之间的差异无关。然而，与转基因的影响相比，品系或父系的影响相对较小，无论父系来源如何，它们都是一致的。因此，来自单一来源种群的 GH 转基因鱼的研究结果可以为评估来自其他系统的 GH 转基因鲑鱼提供有用的信息。这对于检查转基因渗入不同人群的潜在风险具有重要意义。