Abstract

Introduction

Fetal lower urinary tract obstruction (LUTO) can be mild or severe with oligohydramnios, renal dysplasia and pulmonary hypoplasia. Fetal urine biochemical markers correlate with fetal prognosis and, if favorable, surgical intervention is feasible.

Methods

We report a patient in her 18th gestational week whose fetus was diagnosed with LUTO and underwent fetal urine sampling for calcium, sodium, chloride, beta2-microglobulin and total protein of the routine LUTO panel, with the addition of creatinine, glucose, phosphate, urea, ammonia, albumin, and NGAL.

Results

Although the routine fetal urine biochemistry seemed to be favorably trending favorably, sodium, beta2-microglobulin, glucose, and urea did not decrease to the reference ranges, and ammonia and creatinine were lower than the reference ranges. Ultrasound demonstrated no improvement of the obstruction.

Conclusions

This case highlights the need to acquire further experience with biochemical fetal urine markers in order to better manage LUTO.

中文翻译：

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患有尿路梗阻的人类胎儿的尿液生物化学 - 病例报告

摘要

介绍

胎儿下尿路梗阻 (LUTO) 可轻可重，伴有羊水过少、肾发育不良和肺发育不全。胎儿尿液生化标志物与胎儿预后相关，如果有利，手术干预是可行的。

方法

我们报告了一名怀孕 18 周的患者，她的胎儿被诊断出患有 LUTO，并接受了胎儿尿液取样以检测钙、钠、氯、β2-微球蛋白和常规 LUTO 面板的总蛋白，并添加了肌酐、葡萄糖、磷酸盐、尿素、氨、白蛋白和 NGAL。

结果

虽然常规胎儿尿生化似乎有良好的趋势，但钠、β2-微球蛋白、葡萄糖和尿素没有降低到参考范围，氨和肌酐低于参考范围。超声显示阻塞没有改善。

结论

该病例强调需要获得更多关于生化胎儿尿液标记物的经验，以便更好地管理 LUTO。