Abstract

COVID-19 pandemic has created chaos in almost every walk of life. The harsh impact of the disease is mainly rooted to the rapid and easy spread of SARS-CoV-2 virus through airborne and fomite routes. Thus, disinfection of contaminated surfaces and air is important to hamper COVID-19 disease transmission. Ozone being a potent gaseous disinfectant has been utilized to inactivate a wide-range of viruses and has more recently gained interest in the inactivation of SARS-CoV-2. This article critically reviews the current state-of-knowledge on disinfection of surface-adhered and airborne SARS-CoV-2 by ozone. The transmission and survival characteristics of SARS-CoV-2 alongside the specificity of ozone inactivation process are reviewed. Distinct focus is then given to reviewing the status of ozone inactivation of surface-adhered and airborne SARS-CoV-2 in terms of experimental investigations, kinetics, and influence of the operational factors on the inactivation process. Ozone inactivation of SARS-CoV-2 is compared to other enveloped viruses, and the challenges and future prospects of ozone inactivation of SARS-CoV-2 are also addressed.

摘要

COVID-19 大流行几乎在各行各业造成了混乱。该疾病的严重影响主要源于 SARS-CoV-2 病毒通过空气和污染物途径快速而容易地传播。因此，对受污染的表面和空气进行消毒对于阻止 COVID-19 疾病的传播非常重要。臭氧是一种有效的气体消毒剂，已被用于灭活多种病毒，最近人们对灭活 SARS-CoV-2 产生了兴趣。本文批判性地回顾了臭氧对表面粘附和空气传播的 SARS-CoV-2 进行消毒的最新知识。综述了 SARS-CoV-2 的传播和生存特征以及臭氧灭活过程的特异性。然后，根据实验研究、动力学和操作因素对灭活过程的影响，重点审查了表面粘附和空气传播的 SARS-CoV-2 的臭氧灭活状态。将 SARS-CoV-2 的臭氧灭活与其他包膜病毒进行了比较，还讨论了 SARS-CoV-2 臭氧灭活的挑战和未来前景。