Chiral graphene-based supramolecular hydrogels toward tumor therapy,Polymer Chemistry

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Chiral graphene-based supramolecular hydrogels toward tumor therapy
Polymer Chemistry ( IF 4.1 ) Pub Date : 2022-02-17 , DOI: 10.1039/d1py01724a
Xueqian Wang ₁ , Beibei Wu ₁ , Yaqian Zhang ₁ , Chuanliang Feng ₁

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Drugs with a chiral property are playing very important roles in the precise treatment of diseases (especially antitumor drugs); however, the enantioselective delivery of chiral anticancer drugs is still a challenge. Herein, a chiral hydrogel system is constructed by the co-assembly of the D-phenylalanine derivative gelator (DPFEG) with graphene oxide (GO). The chiral property can be regulated by near-infrared light irradiation, which makes it an ideal material for the on-demand control of chiral anticancer drug (oxaliplatin) release. In the absence of infrared light, the drug molecules can hardly leak out of the system for up to seven hours and the drugs can be released upon near-infrared light irradiation. Meanwhile, the light-heat conversion characteristics of GO enable the material to be capable of photothermal therapy. Consequently, the DPFEG-GO material shows a good suppression effect on T47D breast cancer cells. This exquisitely designed supramolecular system provides a simple and effective method for the absorption and precise release of chiral drugs, which has potential for the combination of chemotherapy and photothermal-therapy in the treatment of cancer.

中文翻译：

手性石墨烯基超分子水凝胶用于肿瘤治疗

手性药物在疾病的精准治疗中发挥着非常重要的作用（尤其是抗肿瘤药物）；然而，手性抗癌药物的对映选择性递送仍然是一个挑战。在这里，手性水凝胶系统是由D的共组装构建的。-苯丙氨酸衍生物凝胶剂 (DPFEG) 与氧化石墨烯 (GO)。通过近红外光照射可以调节手性特性，使其成为按需控制手性抗癌药物（奥沙利铂）释放的理想材料。在没有红外光的情况下，药物分子在长达 7 小时内几乎不会漏出系统，而在近红外光照射下，药物可以释放出来。同时，GO的光热转换特性使该材料能够进行光热治疗。因此，DPFEG-GO材料对T47D乳腺癌细胞表现出良好的抑制作用。这种设计精巧的超分子系统为手性药物的吸收和精确释放提供了一种简单有效的方法，

更新日期：2022-02-17

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