This study aimed to investigate the dose– and intensity–response associations between leisure-time physical activity (LTPA) and markers of inflammation and oxidative stress in older adults. Multivariable linear regression was performed to evaluate the associations among 3,559 older adults in 2015–2018 National Health and Nutrition Examination Survey. LTPA was negatively associated with inflammatory markers including C-reactive protein, segmented neutrophil count and alkaline phosphatase, and positively associated with one marker of antioxidants albumin in older adults. Compared with vigorous LTPA, moderate LTPA could provide more benefits through further decreasing white blood cell count and alkaline phosphatase, and increasing serum bilirubin and albumin. The effects of LTPA on C-reactive protein and albumin were more significant in participants with chronic diseases including diabetes, hypertension, and cancer. In conclusion, this study demonstrates the dose– and intensity–response effects of LTPA on inflammation and oxidative stress and provides exercise prescription recommendations for older adults.

本研究旨在调查老年人休闲体育活动 (LTPA) 与炎症和氧化应激标志物之间的剂量和强度反应关联。在 2015-2018 年全国健康和营养检查调查中，对 3,559 名老年人进行了多变量线性回归评估。LTPA 与包括 C 反应蛋白、分段中性粒细胞计数和碱性磷酸酶在内的炎症标志物呈负相关，并与老年人的一种抗氧化剂白蛋白标志物呈正相关。与剧烈LTPA相比，适度LTPA可通过进一步降低白细胞计数和碱性磷酸酶、升高血清胆红素和白蛋白来提供更多获益。LTPA 对 C 反应蛋白和白蛋白的影响在患有糖尿病、高血压和癌症等慢性疾病的参与者中更为显着。总之，这项研究证明了 LTPA 对炎症和氧化应激的剂量和强度反应效应，并为老年人提供了运动处方建议。