Introduction Quality of life (QOL) in older children, adolescents, and adults with cerebral palsy (CP) is significantly impaired. Level of functioning is one of the probable determinants of impairment in QOL. However, such studies in young children with CP are scarce in the literature. Methods Parents of all consecutive children aged between 1 and 4 years with a confirmed diagnosis of CP completed the Infant Toddler Quality of Life (ITQOL) questionnaire. Total and individual subdomain scores of ITQOL were examined for association with the level of functioning measured by Gross Motor Function Classification System—Expanded & Revised (GMFCS E&R), Mini-Manual Ability Classification System (Mini-MACS), Communication Function Classification System (CFCS), and Eating and Drinking Ability Classification System (EDACS), with/without adjustment to probable confounding variables. Results One hundred three children with CP (74 boys, mean age: 2.6 ± 0.9 years, 49% lower and 39% middle socioeconomic status) were enrolled. All four scales (GMFCS, Mini-MACS, CFCS, and EDACS) describing levels of functioning had significant association with ITQOL total score (β= –0.19, –0.15, –0.11, –0.09, respectively), which persisted even after adjusting for confounding variables (p = 0.004, 0.01, 0.03, and 0.046, respectively). Among the confounding variables, uncontrolled seizures, significant vision impairment, lower socioeconomic status, type of CP, and institution of comprehensive rehabilitation measures for ≥6 months had a significant association with ITQOL score (p = 0.03, 0.04, 0.02, 0.02, and 0.01, respectively). Conclusion Level of functioning as measured by GMFCS, Mini-MACS, EDACS, and CFCS is independent predictors of impairment in QOL in young children with CP.

中文翻译：

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脑瘫幼儿的生活质量及其与功能水平的关系

简介 患有脑瘫 (CP) 的大龄儿童、青少年和成人的生活质量 (QOL) 显着受损。功能水平是 QOL 受损的可能决定因素之一。然而，文献中很少有此类针对患有 CP 的幼儿的研究。方法 所有连续诊断为 CP 的 1 至 4 岁儿童的父母完成了婴幼儿生活质量 (ITQOL) 问卷调查。检查 ITQOL 的总分和单个子域得分与通过粗大运动功能分类系统 - 扩展和修订 (GMFCS E&R)、迷你手动能力分类系统 (Mini-MACS)、交流功能分类系统 (CFCS) 测量的功能水平的关联)，以及饮食能力分类系统 (EDACS)，调整/不调整可能的混杂变量。结果 103 名患有 CP 的儿童（74 名男孩，平均年龄：2.6 ± 0.9 岁，低 49% 和 39% 中等社会经济地位）被纳入研究。描述功能水平的所有四个量表（GMFCS、Mini-MACS、CFCS 和 EDACS）都与 ITQOL 总分显着相关（分别为 β = –0.19、–0.15、–0.11、–0.09），即使在调整后仍然存在混杂变量（分别为 p = 0.004、0.01、0.03 和 0.046）。在混杂变量中，不受控制的癫痫发作、显着视力障碍、较低的社会经济地位、CP 类型和综合康复措施机构≥6 个月与 ITQOL 评分显着相关（p = 0.03、0.04、0.02、0.02 和 0.01 ， 分别）。结论 GMFCS 测量的功能水平，