The high neurogenic potential of dental and oral-derived stem cells due to their embryonic neural crest origin, coupled with their ready accessibility and easy isolation from clinical waste, make these ideal cell sources for neuroregeneration therapy. Nevertheless, these cells also have high propensity to differentiate into the osteo-odontogenic lineage. One strategy to enhance neurogenesis of these cells may be to recapitulate the natural physiological electrical microenvironment of neural tissues via electroactive or electroconductive tissue engineering scaffolds. Nevertheless, to date, there had been hardly any such studies on these cells. Most relevant scientific information comes from neurogenesis of other mesenchymal stem/stromal cell lineages (particularly bone marrow and adipose tissue) cultured on electroactive and electroconductive scaffolds, which will therefore be the focus of this review. Although there are larger number of similar studies on neural cell lines (i.e. PC12), neural stem/progenitor cells, and pluripotent stem cells, the scientific data from such studies are much less relevant and less translatable to dental and oral-derived stem cells, which are of the mesenchymal lineage. Much extrapolation work is needed to validate that electroactive and electroconductive scaffolds can indeed promote neurogenesis of dental and oral-derived stem cells, which would thus facilitate clinical applications in neuroregeneration therapy.

由于其胚胎神经嵴起源，牙科和口腔源性干细胞具有很高的神经源性潜力，再加上它们易于获取和易于从临床废物中分离，使这些细胞成为神经再生治疗的理想细胞来源。然而，这些细胞也具有分化成骨牙源性谱系的高倾向。增强这些细胞神经发生的一种策略可能是通过电活性或导电组织工程支架重现神经组织的自然生理电微环境。然而，迄今为止，几乎没有关于这些细胞的此类研究。大多数相关科学信息来自在电活性和导电支架上培养的其他间充质干/基质细胞谱系（特别是骨髓和脂肪组织）的神经发生，因此这将是本综述的重点。尽管有大量关于神经细胞系（即 PC12）、神经干/祖细胞和多能干细胞的类似研究，但此类研究的科学数据与牙科和口腔源性干细胞的相关性和可转化性要低得多，属于间充质谱系。需要大量外推工作来验证电活性和导电支架确实可以促进牙科和口腔源性干细胞的神经发生，从而促进神经再生治疗的临床应用。因此，这将是本次审查的重点。尽管有大量关于神经细胞系（即 PC12）、神经干/祖细胞和多能干细胞的类似研究，但此类研究的科学数据与牙科和口腔源性干细胞的相关性和可转化性要低得多，属于间充质谱系。需要大量外推工作来验证电活性和导电支架确实可以促进牙科和口腔源性干细胞的神经发生，从而促进神经再生治疗的临床应用。因此，这将是本次审查的重点。尽管有大量关于神经细胞系（即 PC12）、神经干/祖细胞和多能干细胞的类似研究，但此类研究的科学数据与牙科和口腔源性干细胞的相关性和可转化性要低得多，属于间充质谱系。需要大量外推工作来验证电活性和导电支架确实可以促进牙科和口腔源性干细胞的神经发生，从而促进神经再生治疗的临床应用。来自此类研究的科学数据与牙齿和口腔来源的干细胞（属于间充质谱系）的相关性和可转化性要低得多。需要大量外推工作来验证电活性和导电支架确实可以促进牙科和口腔源性干细胞的神经发生，从而促进神经再生治疗的临床应用。来自此类研究的科学数据与牙齿和口腔来源的干细胞（属于间充质谱系）的相关性和可转化性要低得多。需要大量外推工作来验证电活性和导电支架确实可以促进牙科和口腔源性干细胞的神经发生，从而促进神经再生治疗的临床应用。