Biocompatible drug-delivery materials are important because they provide controlled release of biologically active agents to enhance the effectiveness of medical treatments. Montmorillonite (Mnt) has been utilized in drug-delivery systems for delayed-release application because it can safely encapsulate drug molecules via intercalation reactions. The objective of the present study was to evaluate the delivery characteristics of the drug ciprofloxacin (CIP) from a composite with Mnt (Mnt-CIP) in which the Mnt was first prepared by acid treatment and vibration ball milling. The surfaces of Mnt were modified by reacting the Mnt suspension in 1.0 M HCl acid and by dispersing the powder with a vibration ball mill, then the CIP drug was added at pH 4 and stirred. The goal was to improve the sustained-release performance of the CIP. This Mnt-CIP drug-release system was characterized by X-ray diffraction, X-ray fluorescence analysis, Fourier-transform infrared spectroscopy, surface area measurement using the Brunauer-Emmett-Teller (BET) method, and ultraviolet spectroscopy. The X-ray diffraction results confirmed the intercalation of CIP into the interlayer space of Mnt. The in vitro release properties of the intercalated CIP were investigated using a simulated phosphate-buffered saline solution (pH 7.4) at 36±0.5°C. The CIP drug exhibited a continued release for 3 h. Moreover, Mnt prepared by HCl acid treatment and dispersion in the vibration ball mill delayed the drug dissolution rate. In summary, the Mnt-CIP composite prepared in this study exhibited slow and sustained release characteristics, indicating that Mnt mined from the Gampo-40 mining area in Gyeongju can be used in various drug-delivery applications.

生物相容性药物递送材料很重要，因为它们提供生物活性剂的受控释放以提高医疗效果。蒙脱石 (Mnt) 已被用于缓释应用的药物输送系统，因为它可以通过嵌入反应安全地封装药物分子。本研究的目的是评估药物环丙沙星 (CIP) 从与 Mnt (Mnt-CIP) 的复合材料中的递送特性，其中 Mnt 首先通过酸处理和振动球磨制备。通过将 Mnt 悬浮液在 1.0 M HCl 酸中反应并用振动球磨机分散粉末来改性 Mnt 的表面，然后在 pH 4 下添加 CIP 药物并搅拌。目标是提高 CIP 的持续释放性能。该 Mnt-CIP 药物释放系统通过 X 射线衍射、X 射线荧光分析、傅里叶变换红外光谱、使用 Brunauer-Emmett-Teller (BET) 方法的表面积测量和紫外光谱来表征。X 射线衍射结果证实了 CIP 嵌入 Mnt 的层间空间。使用模拟磷酸盐缓冲盐水溶液 (pH 7.4) 在 36±0.5°C 下研究嵌入 CIP 的体外释放特性。CIP 药物持续释放 3 小时。此外，通过 HCl 酸处理和在振动球磨机中分散制备的 Mnt 延缓了药物的溶出速率。综上所述，本研究制备的 Mnt-CIP 复合材料具有缓释和缓释特性，