Affective dysregulation (AD) among persons with schizophrenia spectrum disorders, involving the tendency to exhibit sensitivity to minor stress and negative affective states, is an important diagnostic feature and relates to poorer functional and clinical outcomes. Studies of persons with elevated risk for psychosis demonstrate similar AD to those with schizophrenia, and literature suggest a potential influence of AD in the transition from psychosis-like symptoms (PLEs) to disorder. Cross-sectional investigations to date have supported the link between AD and psychosis, and longitudinal studies have mostly yielded mixed findings without demonstration of potential causal relationships between AD and psychosis. This study examined the concurrent and predictive relationships between AD and PLE in a community sample of youth (n = 630) with attention to distinct facets of AD as a latent construct, including low resiliency, low reactive control, and negative emotionality, using structural equation to estimate a longitudinal cross-lagged and autoregressive model across 3 study waves from 15 to 24 years of age. As hypothesized, AD in the mid-teen years predicted subsequent PLE 3 years later. In addition, we found that increasing PLE in the end of the teen years related to a subsequent increase in AD in the early 20s. A cross-sectional relationship between AD and PLE in the mid-teen years was also supported. Findings overall describe important relationships between AD and PLE that appear to vary with developmental stage, implicating various factors to inform approaches for identifying youth who may be at risk for subsequent PLE or other mental health conditions.

中文翻译：

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情感失调先于青年社区样本中类似精神病的经历出现

精神分裂症谱系障碍患者的情感失调 (AD)，涉及对轻微压力和消极情感状态表现出敏感性的倾向，是一个重要的诊断特征，并且与较差的功能和临床结果有关。对精神病风险升高的人的研究表明，AD 与精神分裂症患者相似，文献表明 AD 在从精神病样症状 (PLE) 到障碍的转变中具有潜在影响。迄今为止的横断面调查支持 AD 与精神病之间的联系，而纵向研究大多得出混合的结果，而没有证明 AD 与精神病之间的潜在因果关系。本研究使用结构方程检查了社区青年样本 (n = 630) 中 AD 和 PLE 之间的并发和预测关系，并关注 AD 作为潜在结构的不同方面，包括低弹性、低反应控制和消极情绪估计 15 至 24 岁的 3 个研究波中的纵向交叉滞后和自回归模型。正如假设的那样，青少年中期的 AD 预示着 3 年后的 PLE。此外，我们发现青少年末期 PLE 的增加与随后 20 岁出头 AD 的增加有关。还支持青少年中期 AD 和 PLE 之间的横断面关系。调查结果总体上描述了 AD 和 PLE 之间的重要关系，这些关系似乎随发育阶段而变化，