There is increasing research examining excess mortality in people with bipolar disorder using life expectancy and related measures, which quantify the disease impact on survival. However, there has been no meta-analysis to date summarising existing data on life expectancy in those with bipolar disorder.

To systematically review and quantitatively synthesise estimates of life expectancy and years of potential life lost (YPLL) in people with bipolar disorder.

We searched Embase, Medline, PsycINFO and Web of Science databases up to 31 March 2021. We generated pooled life expectancy using random-effects models, and derived YPLL summary estimate by calculating averaged values weighted by sample size of individual studies. Subgroup analyses were conducted for gender, geographical region, study period, a given age (set-age) for lifespan estimation and causes of death. The study was registered with PROSPERO (CRD42021241705).

Eleven and 13 studies were included in the review for life expectancy (n = 96 601) and YPLL (n = 128 989), respectively. Pooled life expectancy was 66.88 years (95% CI 64.47–69.28; I2 = 99.9%, P < 0.001), was higher in women than men (70.51 (95% CI 68.61–72.41) v. 64.59 (95% CI 61.16–68.03); z = 2.00, P = 0.003) and was lowest in Africa. Weighted average YPLL was 12.89 years (95% CI 12.72–13.07), and was greatest in Africa. More YPLL was observed when lifespan was estimated at birth than at other set-age. YPLLs attributable to natural and unnatural deaths were 5.94 years (95% CI 5.81–6.07) and 5.69 years (95% CI 5.59–5.79), respectively.

Bipolar disorder is associated with substantially shortened life expectancy. Implementation of multilevel, targeted interventions is urgently needed to reduce this mortality gap.

越来越多的研究使用预期寿命和相关措施来检查双相情感障碍患者的超额死亡率，这些措施量化了疾病对生存的影响。然而，迄今为止还没有荟萃分析总结现有的双相情感障碍患者的预期寿命数据。

系统回顾和定量综合估计双相情感障碍患者的预期寿命和潜在生命损失年数 (YPLL)。

我们搜索了截至 2021 年 3 月 31 日的 Embase、Medline、PsycINFO 和 Web of Science 数据库。我们使用随机效应模型生成汇总预期寿命，并通过计算按个别研究样本量加权的平均值得出 YPLL 汇总估计值。对性别、地理区域、研究时期、寿命估计的给定年龄（设定年龄）和死亡原因进行亚组分析。该研究已在 PROSPERO (CRD42021241705) 注册。

预期寿命（n = 96 601）和 YPLL（n = 128 989）分别纳入了 11 项和 13 项研究。综合预期寿命为 66.88 年（95% CI 64.47–69.28；I 2 = 99.9%，P < 0.001），女性高于男性（70.51（95% CI 68.61–72.41）v .64.59（95% CI 61.16– 68.03)；z = 2.00, P = 0.003)，在非洲最低。加权平均 YPLL 为 12.89 年（95% CI 12.72–13.07），在非洲最大。与其他设定年龄相比，在出生时估计寿命时观察到更多的 YPLL。可归因于自然和非自然死亡的 YPLL 分别为 5.94 年（95% CI 5.81-6.07）和 5.69 年（95% CI 5.59-5.79）。

双相情感障碍与预期寿命大大缩短有关。迫切需要实施多层次、有针对性的干预措施，以缩小这一死亡率差距。