Canadian Journal of Fisheries and Aquatic Sciences, Ahead of Print.
Successful integrated management of the invasive predatory sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes of North America is owed largely to the long history of beneficial use of two lampricides: 3-trifluoromethyl-4-nitrophenol (TFM) and 2′,5-dichloro-4′-nitrosalicylanilide (niclosamide). Ensuring continued successful sea lamprey control necessitates consideration of possible next-generation lampricides to supplement or replace current lampricides. This review identifies fifteen hallmarks of success for current lampricides to be used as design criteria in a search for next-generation lampricides. A three-stage research approach is outlined. Targeted research using omics, computer modelling, and high-throughput technology to define molecular mechanisms and high probability molecular targets for sea lamprey selective toxic action is crucial to prioritizing chemical candidates. Targeted delivery or identifying synergists to existing or new lampricides can provide increased efficiency and reduced environmental impact. Ultimate development of next-generation lampricides will rely on traditional toxicity testing methodologies to ensure safety and regulatory compliance.

中文翻译：

---

下一代杀灭灯剂：开发改进的入侵海七鳃鳗控制工具的三阶段过程

加拿大渔业和水生科学杂志，印刷前。
北美劳伦森大湖入侵性捕食性海七鳃鳗 (Petromyzon marinus) 的成功综合管理很大程度上归功于两种杀灭灯剂的有益使用历史悠久：3-三氟甲基-4-硝基苯酚 (TFM) 和 2',5 -二氯-4'-亚硝基水杨酰苯胺（氯硝柳胺）。确保继续成功控制海七鳃鳗需要考虑可能的下一代杀灭灯剂，以补充或替代目前的灭灯剂。本综述确定了当前杀灭灯剂的 15 个成功标志，可用作寻找下一代杀灭灯剂的设计标准。概述了一个三阶段的研究方法。使用组学、计算机建模、确定海七鳃鳗选择性毒性作用的分子机制和高概率分子靶标的高通量技术对于确定化学候选物的优先级至关重要。有针对性地交付或识别现有或新杀灭灯剂的增效剂可以提高效率并减少对环境的影响。下一代杀灭灯剂的最终开发将依赖于传统的毒性测试方法来确保安全性和法规遵从性。