Prompt and sufficient broad-spectrum empirical antibiotic treatment is key to preventing infection following open tibial fractures. Succeeding co-administration, we dynamically assessed the time for which vancomycin and meropenem concentrations were above relevant epidemiological cut-off (ECOFF) minimal inhibitory concentrations (T > MIC) in tibial compartments for the bacteria most frequently encountered in open fractures. Low and high MIC targets were applied: 1 and 4 µg/ml for vancomycin, and 0.125 and 2 µg/ml for meropenem.

中文翻译：

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万古霉素和美罗培南联合治疗后胫骨和软组织浓度——通过猪模型中的微透析评估：开放性骨折患者是否应该使用更高剂量的抗生素？

及时和充分的广谱经验性抗生素治疗是预防开放性胫骨骨折后感染的关键。成功共同给药后，我们动态评估了胫骨隔室中万古霉素和美罗培南浓度高于开放性骨折中最常遇到的细菌的相关流行病学临界值 (ECOFF) 最小抑制浓度 (T > MIC) 的时间。应用了低和高 MIC 目标：万古霉素 1 和 4 µg/ml，美罗培南 0.125 和 2 µg/ml。