Background

Periosteum plays a significant role in bone formation and regeneration by storing progenitor cells, and also acts as a source of local growth factors and a scaffold for recruiting cells and other growth factors. Recently, tissue-engineered periosteum has been studied extensively and shown to be important for osteogenesis and chondrogenesis. Using biomimetic methods for artificial periosteum synthesis, membranous tissues with similar function and structure to native periosteum are produced that significantly improve the efficacy of bone grafting and scaffold engineering, and can serve as direct replacements for native periosteum. Many problems involving bone defects can be solved by preparation of idealized periosteum from materials with different properties using various techniques.

Methods

This review summarizes the significance of periosteum for osteogenesis and chondrogenesis from the aspects of periosteum tissue structure, osteogenesis performance, clinical application, and development of periosteum tissue engineering. The advantages and disadvantages of different tissue engineering methods are also summarized.

Results

The fast-developing field of periosteum tissue engineering is aimed toward synthesis of bionic periosteum that can ensure or accelerate the repair of bone defects. Artificial periosteum materials can be similar to natural periosteum in both structure and function, and have good therapeutic potential. Induction of periosteum tissue regeneration and bone regeneration by biomimetic periosteum is the ideal process for bone repair.

Conclusions

Periosteum is essential for bone formation and regeneration, and it is indispensable in bone repair. Achieving personalized structure and composition in the construction of tissue engineering periosteum is in accordance with the design concept of both universality and emphasis on individual differences and ensures the combination of commonness and individuality, which are expected to meet the clinical needs of bone repair more effectively.

The translational potential of this article

To better understand the role of periosteum in bone repair, clarify the present research situation of periosteum and tissue engineering periosteum, and determine the development and optimization direction of tissue engineering periosteum in the future. It is hoped that periosteum tissue engineering will play a greater role in meeting the clinical needs of bone repair in the future, and makes it possible to achieve optimization of bone tissue therapy.

中文翻译：

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骨膜及其引导骨再生组织工程骨膜的研制

背景

骨膜通过储存祖细胞在骨形成和再生中发挥重要作用，并且还充当局部生长因子的来源和募集细胞和其他生长因子的支架。最近，组织工程骨膜已被广泛研究并显示对成骨和软骨形成很重要。采用仿生方法合成人工骨膜，制备出与天然骨膜功能和结构相似的膜组织，显着提高骨移植和支架工程的疗效，可直接替代天然骨膜。许多涉及骨缺损的问题可以通过使用各种技术从具有不同特性的材料制备理想化的骨膜来解决。

方法

本文从骨膜组织结构、成骨性能、临床应用、骨膜组织工程发展等方面总结了骨膜对成骨和软骨形成的意义。还总结了不同组织工程方法的优缺点。

结果

骨膜组织工程快速发展的领域旨在合成能够确保或加速骨缺损修复的仿生骨膜。人工骨膜材料在结构和功能上均可与天然骨膜相似，具有良好的治疗潜力。仿生骨膜诱导骨膜组织再生和骨再生是骨修复的理想过程。

结论

骨膜对于骨的形成和再生是必不可少的，在骨修复中也是不可缺少的。在组织工程骨膜的构建中实现个性化的结构和组成，符合通用性和强调个体差异性的设计理念，确保共性与个性相结合，有望更有效地满足骨修复的临床需求。

本文的翻译潜力

为更好地了解骨膜在骨修复中的作用，明确骨膜和组织工程骨膜的研究现状，确定组织工程骨膜未来的发展和优化方向。希望骨膜组织工程在满足未来骨修复的临床需求方面发挥更大的作用，使骨组织治疗的优化成为可能。