Geroprotectors slow down aging and promote healthy longevity in model animals. Although hundreds of compounds have been shown to extend the life of laboratory model organisms, clinical studies on potential geroprotectors are exceedingly rare, especially in healthy elders. This review aims to classify potential geroprotectors based on the mechanisms by which they influence aging. These pharmacological interventions can be classified into the following groups: those that prevent oxidation; proteostasis regulators; suppressors of genomic instability; epigenetic drugs; those that preserve mitochondrial function; inhibitors of aging-associated signaling pathways; hormetins; senolytics/senostatics; anti-inflammatory drugs; antifibrotic agents; neurotrophic factors; factors preventing the impairment of barrier function; immunomodulators; and prebiotics, metabiotics, and enterosorbents.

Geroprotectors 减缓衰老并促进模型动物的健康长寿。尽管数百种化合物已被证明可以延长实验室模式生物的寿命，但关于潜在老年保护剂的临床研究极为罕见，尤其是在健康的老年人中。本综述旨在根据潜在的老年保护剂影响衰老的机制对它们进行分类。这些药物干预可分为以下几组： 防止氧化；蛋白质稳态调节剂；基因组不稳定性的抑制因子；表观遗传药物；那些保留线粒体功能的；衰老相关信号通路的抑制剂；激素; senolytics/senostatics; 消炎药；抗纤维化剂；神经营养因子；防止屏障功能受损的因素；免疫调节剂；和益生元，