OBJECTIVE Transdiagnostic models of youth psychopathology posit shared, underlying core features of emotional disorders that confer risk for and/or maintain symptoms. Youth may differ in the presence and severity of these underlying core features, and matching intervention strategies to such features may help personalize transdiagnostic interventions. We used latent profile analysis (LPA) to identify profiles of youth based on core underlying transdiagnostic dysfunctions and examined associations of profiles with treatment outcome. METHOD LPA was conducted with 298 youth ages 7-18.8 (Mage = 12, SD = 3.2; 48.7% female; primarily White and Hispanic/Latinx) with a primary emotional disorder. Indicators for LPA included self-report measures of affect, anxiety sensitivity (AS), distress tolerance (DT), and emotion regulation (ER). Longitudinal associations between profile membership and treatment outcome were examined in a subset of 177 youth (Mage = 11.8, SD = 3.2; 52% female; primarily White and Hispanic/Latinx). RESULTS LPA identified three profiles characterized by differing levels of DT, affect, and ER. A Moderately Distressed and Dysregulated profile had the largest membership (65.1%) and poorer youth-reported anxiety and depression outcomes compared to a Distress Tolerant, Regulated Expressive profile (24.9%). A Distressed, High Affect Avoidant profile (10%) had the greatest baseline severity and the poorest depression outcomes, although most youth improved. CONCLUSIONS Youth characterized by certain profiles of transdiagnostic core processes appear to have the poorest functioning and treatment prognosis, although most youth improved. Targeting these processes more directly and/or earlier in treatment may help to improve outcomes for youth. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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一种以人为本的方法来了解接受情绪障碍跨诊断治疗的青年的异质性。

目标 青年精神病理学的跨诊断模型假设情绪障碍的共同的、潜在的核心特征赋予风险和/或维持症状。青少年在这些潜在核心特征的存在和严重程度方面可能有所不同，将干预策略与这些特征相匹配可能有助于个性化跨诊断干预。我们使用潜在概况分析 (LPA) 根据核心潜在的跨诊断功能障碍来识别青年概况，并检查概况与治疗结果的关联。方法 LPA 对 298 名患有原发性情绪障碍的 7-18.8 岁青年（Mage = 12，SD = 3.2；48.7% 女性；主要是白人和西班牙裔/拉丁裔）进行。LPA 的指标包括情感、焦虑敏感性 (AS)、痛苦耐受性 (DT) 和情绪调节 (ER) 的自我报告测量。在 177 名青年（Mage = 11.8，SD = 3.2；52% 女性；主要是白人和西班牙裔/拉丁裔）的子集中检查了档案成员资格和治疗结果之间的纵向关联。结果 LPA 确定了三个特征，其特征是 DT、情感和 ER 的不同水平。中度苦恼和失调的情况下，成员人数最多（65.1%），而青少年报告的焦虑和抑郁结果与苦恼耐受、受监管的表达情况（24.9%）相比更差。尽管大多数年轻人有所改善，但苦恼、高情感回避型 (10%) 的基线严重程度最高，抑郁结果最差。结论 以某些跨诊断核心过程为特征的青年似乎具有最差的功能和治疗预后，尽管大多数青年有所改善。在治疗中更直接和/或更早地针对这些过程可能有助于改善青少年的结果。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。