Because dementia with Lewy bodies (DLB) has various psychiatric symptoms, early diagnosis in patients without parkinsonism is difficult. To reveal associations between regional brain perfusion and psychiatric symptoms in DLB patients without parkinsonism, we quantified brain perfusion using an automated brain perfusion single-photon emission computed tomography analysis program, FineSRT. We statistically analyzed the differences in brain perfusion between groups, divided by the presence or absence of psychiatric symptoms. In DLB patients with depression, there were significant brain perfusion increases in the left angular gyrus and right upper precuneus. In DLB patients with visual hallucinations, there were significant decreases in the left inferior parietal lobule, left superior temporal gyrus, and right primary visual cortex. In DLB patients with auditory hallucinations, there were significant increases in the right middle occipital and right inferior occipital gyri. Our findings provide clues about the pathomechanisms of psychiatric symptoms and may enable early diagnosis of DLB in the future.

由于路易体痴呆（DLB）具有多种精神症状，因此对无帕金森病的患者进行早期诊断很困难。为了揭示无帕金森病的 DLB 患者的区域脑灌注与精神症状之间的关联，我们使用自动脑灌注单光子发射计算机断层扫描分析程序 FineSRT 量化了脑灌注。我们统计分析了各组之间脑灌注的差异，并除以是否存在精神症状。在患有抑郁症的 DLB 患者中，左角回和右上楔前叶的脑灌注显着增加。在出现幻视的 DLB 患者中，左侧顶下小叶、左侧颞上回和右侧初级视觉皮层显着减少。出现幻听的 DLB 患者，右侧枕中回和右侧枕下回显着增大。我们的研究结果提供了有关精神症状病理机制的线索，并可能在未来实现 DLB 的早期诊断。