Identification of Two Novel HIV-1 Unique Recombinant Forms in Shenzhen, China,AIDS Research and Human Retroviruses

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Identification of Two Novel HIV-1 Unique Recombinant Forms in Shenzhen, China
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2022-06-06 , DOI: 10.1089/aid.2021.0229
Yang Li _{1,

2} , Bo Zhu _{1,

2} , Jingwan Han ₂ , Jingyun Li ₂ , Lei Jia ₂ , Xiaolin Wang ₂ , Hanping Li ₂ , Lin Li _{1,

2}

Affiliation

Homosexual contact is one of the main transmission routes of the HIV-1 epidemic in Shenzhen. Several subtypes of HIV-1 are prevalent among men who have sex with men simultaneously, which provides favorable conditions for the formation of a unique recombinant form (URF). In this study, we reported two URFs of HIV-1 (LS10525 and LS13740) infected through homosexual contact in Shenzhen. Phylogeny and recombination analyses based on the nearly full-length genome indicated that LS10525 was a second-generation recombinant strain composed of circulating recombinant form (CRF)07_BC and CRF59_01B, and LS13740 was a second-generation recombinant strain composed of CRF07_BC and CRF55_01B. The emergence of the novel structure of URFs urgently needs to surveil the HIV-1 epidemic in the population.

更新日期：2022-06-08

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