ABSTRACT

Although permethrin has low toxicity in mammals, it affects many aquatic organisms directly or indirectly due to its high insecticide potential. In this study, changes in the levels of some hormones, cytokines and histopathological effects in the gill and liver were studied in common carp (Cyprinus carpio) exposed to permethrin at different doses (0, 10 and 20 ppm) and durations (4 days and 21 days). Permethrin exposure showed significant (P < 0.05) elevation in the serum levels of adrenocorticotropic hormone (ACTH), cortisol (CORT), tumor necrosis factor-α (TNF-α), interleukin 1β (IL- 1β) and interleukin 6 (IL-6) while decrease in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in duration- and concentration dependent-manner compared to the control group. Histopathological findings such as reduction in secondary interlamellar space in the gill tissue, shortening of secondary lamellae, merging, fusion, oedema and telangiectasia were obtained. In the liver tissue, histopathological symptoms such as vacuolization of hepatocytes, passive hyperaemia, mononuclear cell infiltration and hepatocellular degeneration were observed. As a result, it was determined that permethrin had a toxic effect on common carp depending on the dose and duration exposure.

摘要

虽然氯菊酯对哺乳动物的毒性很低，但由于其高杀虫潜力，它直接或间接影响许多水生生物。在这项研究中，研究了鲤鱼（Cyprinus carpio）在不同剂量（0、10 和 20 ppm）和持续时间（4 天和21 天）。氯菊酯暴露显着（P < 0.05) 血清促肾上腺皮质激素 (ACTH)、皮质醇 (CORT)、肿瘤坏死因子-α (TNF-α)、白细胞介素 1β (IL-1β) 和白细胞介素 6 (IL-6) 水平升高，同时生长减少与对照组相比，激素（GH）和胰岛素样生长因子-1（IGF-1）的持续时间和浓度依赖方式。获得组织病理学发现，例如鳃组织中的次级板层空间减少，次级板层缩短，合并，融合，水肿和毛细血管扩张。在肝组织中，观察到肝细胞空泡化、被动充血、单核细胞浸润和肝细胞变性等组织病理学症状。结果，确定氯菊酯对鲤鱼有毒性作用，具体取决于剂量和持续时间。