Flavonoids, a class of plant phenolic compounds, act as plant defense chemicals. Chrysoeriol is a naturally occurring flavonoid produced by Melientha suavis Pierre. The goal of this study was to investigate the insecticidal potential and mode of action of chrysoeriol isolated from M. suavis against Spodoptera litura (Fabricius). The effects of chrysoeriol on second-instar S. litura larvae were determined by topical application. Chrysoeriol was highly toxic to S. litura (24- and 48-h LD50 values of ~ 6.99 and 6.51 µg/larva, respectively). Moreover, mode-of-action experiments demonstrated that this compound significantly decreased the activities of both detoxification-related enzymes [carboxylesterases (CarE) and glutathione S-transferase (GST)] and neurological enzymes (acetylcholinesterase). These results indicate that chrysoeriol isolated from M. suavis could be used as a potential agent with activity against S. litura. However, it is necessary to determine the potential side effects on nontarget species for the further development of these novel insecticides.

中文翻译：

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从香蜂草中分离出具有抗农业害虫斜纹夜蛾活性的金黄菊醇

黄酮类化合物是一类植物酚类化合物，可作为植物防御化学品。Chrysoeriol 是一种由 Melientha suavis Pierre 生产的天然类黄酮。本研究的目的是研究从 M. suavis 中分离出来的金黄菊醇对斜纹夜蛾 (Fabricius) 的杀虫潜力和作用方式。通过局部应用确定金黄菊醇对二龄斜纹夜蛾幼虫的影响。Chrysoeriol 对 S. litura 具有剧毒（24 小时和 48 小时 LD50 值分别为 ~ 6.99 和 6.51 µg/幼虫）。此外，作用模式实验表明，该化合物显着降低了解毒相关酶 [羧酸酯酶 (CarE) 和谷胱甘肽 S-转移酶 (GST)] 和神经系统酶 (乙酰胆碱酯酶) 的活性。这些结果表明从 M. suavis 可用作对 S. litura 具有活性的潜在药剂。然而，为了进一步开发这些新型杀虫剂，有必要确定对非目标物种的潜在副作用。