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Black pepper (Piper nigrum) fruit-based gold nanoparticles (BP-AuNPs): Synthesis, characterization, biological activities, and catalytic applications – A green approach
Green Processing and Synthesis ( IF 3.8 ) Pub Date : 2022-01-01 , DOI: 10.1515/gps-2022-0002
Sami Bawazeer 1 , Ibrahim Khan 2 , Abdur Rauf 2 , Abdullah S. M. Aljohani 3 , Fahad A. Alhumaydhi 4 , Anees Ahmed Khalil 5 , Muhammad Nasimullah Qureshi 2 , Laiba Ahmad 6 , Shahid Ali Khan 2
Affiliation  

As compared to conventional techniques, currently nanotechnology has gained significant attention of scientists for the development of plant-based natural nanoparticles (NPs) due to their safety, effectiveness, and environment friendly nature. The current study was aimed for development, characterization (energy-dispersive X-ray, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy), and evaluation of the biological efficiency of black pepper (BP; Piper nigrum ) fruit-based gold NPs (BP-AuNPs) through different in vitro and in vivo assays. BP extract revealed maximum antibacterial and antifungal potential against Escherichia coli (24 mm) and Aspergillus flavus (47 mm), respectively. However, BP-AuNPs (200 µg·mL −1 ) inhibited the urease, xanthine oxidase, and carbonic acid-II activities with a percent inhibition of 83.11%, 91.28%, and 86.87%, respectively. Further, the anti-inflammatory effect of BP extract at the dose of 100 mg·kg −1 was 72.66%, whereas for BP-AuNPs it was noticed to be 91.93% at the dose of 10 mg·kg −1 . Similarly, the extract of BP and prepared AuNPs demonstrated significant ( p < 0.01) sedative effect at all tested doses. The BP-AuNPs catalytically reduced methyl orange dye. Results suggest that BP-AuNPs possess significant biological activities, and further studies must be conducted to identify the probable mechanism of action associated with these activities. Graphical abstract

中文翻译:

黑胡椒 (Piper nigrum) 基于水果的金纳米粒子 (BP-AuNPs):合成、表征、生物活性和催化应用——一种绿色方法

与传统技术相比,目前纳米技术因其安全性、有效性和环境友好性而受到科学家们的极大关注,以开发基于植物的天然纳米颗粒(NPs)。目前的研究旨在开发、表征(能量色散 X 射线、紫外-可见光谱、傅里叶变换红外光谱和扫描电子显微镜),并评估黑胡椒 (BP; Piper nigrum) 果实的生物效率基于金纳米粒子(BP-AuNPs)通过不同的体外和体内测定。BP 提取物分别显示对大肠杆菌(24 毫米)和黄曲霉(47 毫米)的最大抗菌和抗真菌潜力。然而,BP-AuNPs (200 µg·mL -1 ) 抑制脲酶、黄嘌呤氧化酶、和碳酸-II 活性,抑制百分比分别为 83.11%、91.28% 和 86.87%。此外,BP 提取物在 100 mg·kg -1 剂量下的抗炎作用为 72.66%,而 BP-AuNPs 在 10 mg·kg -1 剂量下的抗炎作用为 91.93%。同样,BP 提取物和制备的 AuNPs 在所有测试剂量下都表现出显着的 (p < 0.01) 镇静作用。BP-AuNPs 催化还原甲基橙染料。结果表明,BP-AuNPs 具有显着的生物活性,必须进行进一步的研究以确定与这些活性相关的可能作用机制。图形概要 而对于 BP-AuNPs,在 10 mg·kg -1 的剂量下它被注意到为 91.93%。同样,BP 提取物和制备的 AuNPs 在所有测试剂量下都表现出显着的 (p < 0.01) 镇静作用。BP-AuNPs 催化还原甲基橙染料。结果表明,BP-AuNPs 具有显着的生物活性,必须进行进一步的研究以确定与这些活性相关的可能作用机制。图形概要 而对于 BP-AuNPs,在 10 mg·kg -1 的剂量下它被注意到为 91.93%。同样,BP 提取物和制备的 AuNPs 在所有测试剂量下都表现出显着的 (p < 0.01) 镇静作用。BP-AuNPs 催化还原甲基橙染料。结果表明,BP-AuNPs 具有显着的生物活性,必须进行进一步的研究以确定与这些活性相关的可能作用机制。图形概要 并且必须进行进一步的研究以确定与这些活动相关的可能的作用机制。图形概要 并且必须进行进一步的研究以确定与这些活动相关的可能的作用机制。图形概要
更新日期:2022-01-01
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