Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field. A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug discovery, production, and modification, and their current applications. We also discuss the value and challenges associated with future developments in therapeutic peptides.

由于新的生产、修饰和分析技术，肽药物开发在过去十年中取得了长足的进步。已经使用化学和生物方法生产和修饰了肽，以及新的设计和递送策略，这有助于克服肽的固有缺陷，并促进该领域的持续发展。已经获得并研究了多种天然和修饰肽，涵盖多个治疗领域。这篇综述总结了多肽药物发现、生产和修饰方面的努力和成就，以及它们目前的应用。我们还讨论了与治疗性肽未来发展相关的价值和挑战。