Abstract

Background:

Some studies have estimated the diagnostic value of procalcitonin (PCT) for Kawasaki disease (KD), but the results are not always consistent. The aim of this study was to ascertain the diagnostic value of PCT for KD.

Methods:

Relevant and eligible articles assessing the diagnostic significance of PCT in KD were systematically searched from PubMed as well as the CNKI databases (last update: October 31, 2020), followed by bivariate models to evaluate the overall diagnostic significance of PCT in KD. This systematic review and meta-analysis included four articles.

Results:

The overall diagnostic specificity and sensitivity were 0.78 (95% CI: 0.74–0.82) and 0.73 (95% CI: 0.69–0.76), respectively. The area under the summary receiver operating characteristic (sROC) curve (AUC) was 0.82. The negative likelihood ratio (NLR) and positive likelihood ratio (PLR) values for PCT were 0.34 and 3.23, respectively.

Conclusions:

By analyzing the accessible articles, we showed PCT is not a particularly useful test for KD diagnosis.

中文翻译：

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降钙素原在预测川崎病中的作用

摘要

背景：

一些研究估计了降钙素原 (PCT) 对川崎病 (KD) 的诊断价值，但结果并不总是一致的。本研究的目的是确定 PCT 对 KD 的诊断价值。

方法：

从 PubMed 和 CNKI 数据库（最后更新时间：2020 年 10 月 31 日）中系统检索了评估 PCT 对 KD 诊断意义的相关且符合条件的文章，然后采用双变量模型评估 PCT 在 KD 中的整体诊断意义。该系统评价和荟萃分析包括四篇文章。

结果：

总体诊断特异性和敏感性分别为 0.78（95% CI：0.74-0.82）和 0.73（95% CI：0.69-0.76）。汇总受试者工作特征 (sROC) 曲线 (AUC) 下面积为 0.82。PCT 的阴性似然比 (NLR) 和阳性似然比 (PLR) 值分别为 0.34 和 3.23。

结论：

通过分析可访问的文章，我们表明 PCT 对 KD 诊断并不是特别有用的测试。