A study in Nature reconstructs haematopoietic phylogenies and tracks clonal evolutionary dynamics in 12 patients with adult-onset myeloproliferative neoplasms, revealing that initial driver mutations of these cancers often occur during childhood, including in utero.

中文翻译：

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使用肿瘤系统发育来识别驱动因素

Nature 杂志上的一项研究重建了 12 名成人发病的骨髓增生性肿瘤患者的造血系统发育并追踪克隆进化动力学，揭示了这些癌症的最初驱动突变通常发生在儿童时期，包括在子宫内。