Nodal modulator (NOMO) is a type I transmembrane protein that is conserved in various human tissues. Humans have three highly similar NOMO proteins, namely NOMO1, NOMO2, and NOMO3. These three proteins are closely related and may have similar functions. NOMO has been identified as a part of a protein complex that mediates a wide range of biological processes such as tumor formation, bone and cartilage formation, embryo formation, facial asymmetry, and development of congenital heart disease. To date, a few studies have focused on the role of NOMO; however, the mechanism underlying its effects remains unknown. To improve our understanding regarding NOMO, we reviewed the role of NOMO in different diseases and investigated the mechanism underlying its effects.

中文翻译：

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节点调节剂的生物学作用：过去两个十年的综合回顾

节点调节剂 (NOMO) 是一种 I 型跨膜蛋白，在各种人体组织中是保守的。人类具有三种高度相似的 NOMO 蛋白，即 NOMO1、NOMO2 和 NOMO3。这三种蛋白质密切相关，可能具有相似的功能。NOMO 已被确定为蛋白质复合物的一部分，该复合物介导广泛的生物过程，如肿瘤形成、骨和软骨形成、胚胎形成、面部不对称和先天性心脏病的发展。迄今为止，一些研究集中在 NOMO 的作用上。然而，其影响背后的机制仍然未知。为了提高我们对 NOMO 的理解，我们回顾了 NOMO 在不同疾病中的作用，并研究了其影响的机制。