Background: 

Hyperbilirubinemia is one of the most frequently occurring problems in the neonatal period, and phototherapy has remained the primary treatment of choice. Fluid supplementation has been proposed to reduce serum bilirubin levels.

Purpose: 

To assess the risks and benefits of fluid supplementation compared with standard fluid management in preterm infants with unconjugated hyperbilirubinemia under conventional phototherapy.

Methods: 

A retrospective cohort study of preterm infants (gestational ages ≥28 to ≤32 weeks) admitted to the neonatal intensive care unit at the Maternity and Children Hospital in Jeddah, Saudi Arabia, from January 1, 2017, to December 31, 2017, and required the initiation of phototherapy in the first week of life.

Results: 

One hundred and fifteen infants were included; 51 received fluid supplementation, and 64 received standard fluid management. There were no significant differences in demographic characteristics between groups. The infants who received fluid supplementation had a significantly larger decline in the total serum bilirubin level per day and a shorter phototherapy duration (P < .01). There were no significant differences in weight (P = .14), or sodium (P = .79) change per day or the need for exchange transfusion between groups. The prematurity-related inhospital morbidities were similar between groups.

Implications for Practice and Research: 

Fluid supplementation in preterm infants receiving conventional phototherapy resulted in a faster decline in the bilirubin level and a shorter duration of phototherapy, without increasing prematurity-related morbidities. Future randomized controlled trials to assess the benefits and risks of fluid supplementation during conventional phototherapy in preterm infants are needed.

中文翻译：

---

高胆红素血症早产儿静脉补液：一项回顾性队列研究

背景： 

高胆红素血症是新生儿期最常见的问题之一，光疗仍然是首选的治疗方法。已提出补充液体以降低血清胆红素水平。

目的： 

评估传统光疗下患有非结合高胆红素血症的早产儿补充液体与标准液体管理相比的风险和益处。

方法： 

一项回顾性队列研究，研究对象为2017年1月1日至2017年12月31日期间入住沙特阿拉伯吉达妇幼医院新生儿重症监护室的早产儿（胎龄≥28周至≤32周），并要求在生命的第一周开始光疗。

结果： 

其中包括一百一十五名婴儿；51 人接受液体补充，64 人接受标准液体管理。各组之间的人口统计学特征没有显着差异。接受液体补充的婴儿每日血清总胆红素水平下降幅度显着较大，且光疗持续时间较短( P < .01)。各组之间的体重 ( P = .14) 或钠 ( P = .79) 每天变化或换血需求没有显着差异。各组之间与早产相关的住院发病率相似。

对实践和研究的影响： 

接受传统光疗的早产儿补充液体会导致胆红素水平更快下降和光疗持续时间更短，而不会增加早产相关的发病率。未来需要进行随机对照试验来评估早产儿传统光疗期间补充液体的益处和风险。