Human papillomavirus (HPV) is the principal risk factor for cervical cancer. Transplant recipients are at a disproportionate risk of HPV complications. We conducted a single-centre, retrospective study of adult female cystic fibrosis (CF) lung transplant recipients between 2008 and 2021. We observed 12 of 34 (35.3%) with ≥1 abnormal pap smear (median age: 26.7 years). Complications included refractory anogenital warts (n=3), vulvectomy (n=2) and cervical cancer (n=4), with two deaths from metastatic disease. None with HPV morbidity was vaccinated. Lung transplant recipients had greater odds of cervical dysplasia relative to controls (OR, 3.98; 95% CI 1.17 to 11.82). CF care providers must prioritise HPV vaccination to attenuate potential future morbidity and mortality.

中文翻译：

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成年女性囊性纤维化 (CF) 肺移植受者的人乳头瘤病毒 (HPV) 和宫颈发育不良

人乳头瘤病毒（HPV）是宫颈癌的主要危险因素。移植受者发生 HPV 并发症的风险不成比例。我们在 2008 年至 2021 年间对成年女性囊性纤维化 (CF) 肺移植受者进行了一项单中心回顾性研究。我们观察到 34 名患者中有 12 名 (35.3%) 有≥1 次巴氏涂片异常（中位年龄：26.7 岁）。并发症包括顽固性肛门生殖器疣 (n=3)、外阴切除术 (n=2) 和宫颈癌 (n=4)，其中 2 人死于转移性疾病。没有 HPV 发病率的人接种了疫苗。与对照组相比，肺移植受者发生宫颈发育不良的几率更高（OR，3.98；95% CI 1.17 至 11.82）。CF 护理提供者必须优先接种 HPV 疫苗，以降低未来潜在的发病率和死亡率。