OBJECTIVE Relationship education programs have proven effective in promoting relationship quality and preventing divorce among married couples. However, according to theories of Environmental Sensitivity, people differ for genetic reasons in their sensitivity to environmental influences with some more affected by both negative and positive experiences, including psychological interventions. METHOD Here we test in two studies whether the positive effects of the established Prevention and Relationship Education Program (PREP) are moderated by two different polygenic scores (PGS) for environmental sensitivity, one based on nine established candidate genes and one based on several thousand variants across the genome, derived from recent genome-wide association study (GWAS) results. Analyses were conducted in a randomized controlled study on PREP (N = 242) and then repeated in an independent replication trial (N = 183). RESULTS Several significant PREP-X-PGS interactions indicated moderation of long-term treatment effects across the two studies, most of them involving the genome-wide score. Generally, higher genome-wide genetic sensitivity was associated with stronger intervention effects on almost all measures of relationship quality across the follow-up period. CONCLUSIONS Findings provide further evidence that people differ substantially in their response to the positive effects of psychological intervention as a function of individual differences in genetic sensitivity, with more sensitive participants potentially benefitting more from relationship education. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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遗传敏感性预测已婚夫妇的关系教育计划的长期心理益处。

目标 关系教育计划已被证明在提高已婚夫妇的关系质量和防止离婚方面是有效的。然而，根据环境敏感性理论，由于遗传原因，人们对环境影响的敏感性不同，有些人更多地受到负面和正面经历的影响，包括心理干预。方法 在这里，我们在两项研究中测试已建立的预防和关系教育计划 (PREP) 的积极影响是否受到两种不同的环境敏感性多基因评分 (PGS) 的调节，一种基于九个已建立的候选基因，另一种基于数千个变异整个基因组，源自最近的全基因组关联研究（GWAS）结果。在一项关于 PREP 的随机对照研究（N = 242）中进行分析，然后在独立的复制试验中重复（N = 183）。结果 几项重要的 PREP-X-PGS 相互作用表明两项研究的长期治疗效果有所缓和，其中大部分涉及全基因组评分。一般来说，更高的全基因组遗传敏感性与在随访期间对几乎所有关系质量测量的更强干预效果相关。结论 研究结果提供了进一步的证据，表明人们对心理干预的积极影响的反应存在显着差异，这是遗传敏感性个体差异的函数，更敏感的参与者可能从关系教育中受益更多。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。