We investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case–control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs), adjusted for education and time at interview. Reduced ORs were observed for glioma in relation to physician-diagnosed asthma (OR = 0.73; CI 0.58–0.92), hay fever (OR 0.72; CI 0.61–0.86), and eczema (OR 0.78, CI 0.64–0.94), but not for meningioma or acoustic neuroma. Previous diagnosis of epilepsy was associated with an increased OR for glioma (2.94; CI 1.87–4.63) and for meningioma (2.12; CI 1.27–3.56), but not for acoustic neuroma. This large-scale case–control study adds to the growing evidence that people with allergies have a lower risk of developing glioma, but not meningioma or acoustic neuroma. It also supports clinical observations of epilepsy prior to the diagnosis of glioma and meningioma.

我们在 Interphone 一项 13 个国家的病例对照研究中调查了过敏性疾病和癫痫与脑肿瘤风险的关联。数据来自 2693 例神经胶质瘤病例、2396 例脑膜瘤病例和 1102 例听神经瘤病例及其 6321 例对照。使用条件逻辑回归模型来估计汇总比值比 (OR) 及其各自的 95% 置信区间 (CI)，并根据教育程度和面试时间进行调整。观察到神经胶质瘤的 OR 降低与医生诊断的哮喘（OR = 0.73； CI 0.58–0.92）、花粉症（OR 0.72； CI 0.61–0.86）和湿疹（OR 0.78，CI 0.64–0.94）相关，但不存在相关性用于脑膜瘤或听神经瘤。既往癫痫诊断与神经胶质瘤（2.94； CI 1.87-4.63）和脑膜瘤（2.12； CI 1.27-3.56）的 OR 增加相关，但与听神经瘤无关。这项大规模病例对照研究进一步证明，过敏人群患神经胶质瘤的风险较低，但患脑膜瘤或听神经瘤的风险较低。它还支持在诊断神经胶质瘤和脑膜瘤之前对癫痫进行临床观察。