ZrO₂-hydroxyapatite composite bioceramics is considered to be a promising material for bone defects recovery, at the same time there are virtually no “in vivo” biotests reported for this system combining modern imaging techniques, histological studies, and blood biochemical analysis. Here we have thoroughly researched biocompatibility of high quality bioceramics based on ZrO₂-(15 wt%)-hydroxyapatite composite fabricated by spark plasma sintering-reactive sintering technique. Implant's osteointegration mechanism was studied for the case of regeneration of the rabbit's cranial bone involving a complex of histological, morphometric, X-ray, and hematological techniques. Bioceramics osteointegration was shown to be efficient, proceeding through ossification of the newly formed cartilaginous tissue and bioceramics-driven bone matrix remodeling in the region of trepanation defect. Obtained results clearly show bright prospects of implementing spark plasma sintered zirconia-hydroxyapatite composite ceramics as a potential implant material for regenerative and bone-reconstructive surgery.

ZrO ₂ -羟基磷灰石复合生物陶瓷被认为是一种很有前途的骨缺损修复材料，同时几乎没有关于该系统结合现代成像技术、组织学研究和血液生化分析的“体内”生物测试报道。_{在这里，我们深入研究了基于 ZrO 2}的高质量生物陶瓷的生物相容性-(15 wt%)-羟基磷灰石复合材料，采用放电等离子烧结-反应烧结技术制备。植入物的骨整合机制在兔子颅骨再生的案例中进行了研究，涉及组织学、形态测量、X 射线和血液学技术的综合体。生物陶瓷骨整合被证明是有效的，通过新形成的软骨组织骨化和生物陶瓷驱动的骨基质在环钻缺损区域重塑。获得的结果清楚地表明了将放电等离子烧结氧化锆-羟基磷灰石复合陶瓷作为再生和骨重建手术的潜在植入材料的广阔前景。