Owing to their good stability and high photothermal conversion efficiency, the development of carbon-based nanoparticles has been intensively investigated, while the limitation of unsatisfactory cellular internalization impedes their further clinical application. Herein, we report a novel strategy for fabrication of Fe3O4 yolk–shell mesoporous carbon nanocarriers (Fe3O4@hmC) with monodispersity and uniform size, which presented significantly higher cell membrane adsorption and cellular uptake properties in comparison with common solid silica-supported mesoporous carbon nanoparticles with core–shell structure. Moreover, the MRI performance of this novel Fe-based nanoparticle could facilitate precise tumor diagnosis. More importantly, after DOX loading (Fe3O4@hmC-DOX), owing to synergistic effect of chemo–phototherapy, this therapeutic agent exhibited predominant tumor cell ablation capability under 808 nm NIR laser irradiation, both in vitro and in vivo. Our work has laid a solid foundation for therapeutics with hollowed carbon shell for solid tumor diagnosis and therapy in clinical trials.

中文翻译：

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一种新型蛋黄壳 Fe3O4@ 介孔碳纳米颗粒作为一种有效的肿瘤靶向纳米载体，用于改善化疗和光热治疗

由于其良好的稳定性和较高的光热转换效率，碳基纳米粒子的开发受到了深入研究，而细胞内化不足的局限性阻碍了其进一步的临床应用。在此，我们报告了一种制备具有单分散性和均匀尺寸的 Fe3O4 蛋黄壳介孔碳纳米载体 (Fe3O4@hmC) 的新策略，与常见的固体二氧化硅负载的介孔碳纳米粒子相比，它具有显着更高的细胞膜吸附和细胞吸收性能。具有核壳结构。此外，这种新型铁基纳米颗粒的 MRI 性能可以促进精确的肿瘤诊断。更重要的是，在 DOX 负载（Fe3O4@hmC-DOX）后，由于化学-光疗的协同作用，该治疗剂在体外和体内均在 808 nm NIR 激光照射下表现出显着的肿瘤细胞消融能力。我们的工作为临床试验中用于实体瘤诊断和治疗的空心碳壳疗法奠定了坚实的基础。