Wound management is an unmet therapeutic challenge and a global healthcare burden. Current treatment strategies provide limited efficiency in wound management, thus undergoing constant evolution in the treatment approaches. As wound healing is a complex physiological process involving precise synchronization of various phases like hemostasis, inflammation and remodelling, which necessitates innovative treatment strategies. Nanotechnology platforms like polymeric nanofibers (NFs) offer a promising solution for wound management. NFs contain a porous mesh-like structure that mimics the natural extracellular matrix and promote the cell adhesion and proliferation in the wound bed, thus displaying a great potential as a wound healing scaffold. Electrospinning is a simple, versatile and scalable technique for producing highly porous and tuneable NFs with a high surface area. Electrospun NFs are presenting extensive application in wound management, especially for burns and diabetic foot ulcers. This review briefly discusses the wound physiology and conventional treatment strategies. It also provides an overview of the electrospinning process and its principle, highlighting the application of electrospun polymeric NFs in wound management. The authors have made an attempt to emphasizes on the clinical challenges and future perspectives along with regulatory aspects of NFs as a wound dressing.

中文翻译：

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用于伤口愈合的电纺纳米纤维的最新进展：聚合物、临床和监管视角

伤口管理是一项尚未解决的治疗挑战和全球医疗保健负担。目前的治疗策略在伤口管理方面的效率有限，因此治疗方法不断发展。由于伤口愈合是一个复杂的生理过程，涉及止血、炎症和重塑等各个阶段的精确同步，因此需要创新的治疗策略。聚合物纳米纤维 (NFs) 等纳米技术平台为伤口管理提供了有前景的解决方案。NFs 含有多孔网状结构，可模拟天然细胞外基质，促进伤口床中的细胞粘附和增殖，因此显示出作为伤口愈合支架的巨大潜力。静电纺丝很简单，通用且可扩展的技术，用于生产具有高表面积的高度多孔和可调节的 NF。静电纺丝 NF 在伤口管理中呈现出广泛的应用，特别是对于烧伤和糖尿病足溃疡。本综述简要讨论了伤口生理学和常规治疗策略。它还概述了静电纺丝工艺及其原理，重点介绍了静电纺丝聚合物 NF 在伤口管理中的应用。作者试图强调临床挑战和未来前景以及 NFs 作为伤口敷料的监管方面。它还概述了静电纺丝工艺及其原理，重点介绍了静电纺丝聚合物 NF 在伤口管理中的应用。作者试图强调临床挑战和未来前景以及 NFs 作为伤口敷料的监管方面。它还概述了静电纺丝工艺及其原理，重点介绍了静电纺丝聚合物 NF 在伤口管理中的应用。作者试图强调临床挑战和未来前景以及 NFs 作为伤口敷料的监管方面。