Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma,Clinical and Translational Medicine

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Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma
Clinical and Translational Medicine ( IF 7.919 ) Pub Date : 2022-01-24 , DOI: 10.1002/ctm2.660
Ai Zhuang _{1,

2} , Peiwei Chai _{1,

2} , Shaoyun Wang _{1,

2} , Sipeng Zuo _{1,

2} , Jie Yu _{1,

2} , Shichong Jia _{1,

2} , Shengfang Ge _{1,

2} , Renbing Jia _{1,

2} , Yixiong Zhou _{1,

2} , Wodong Shi _{1,

2} , Xiaofang Xu _{1,

2} , Jing Ruan _{1,

2} , Xianqun Fan _{1,

2}

Affiliation

To explore the therapeutic potential and the underlying mechanism of metformin, an adenosine monophosphate-activated kinase (AMPK) activator, in ocular melanoma.

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