The number of studies of controlled drug-release systems is growing constantly. Bionanocomposite materials which can be prepared from the combination of biopolymers with inorganic solids such as clay minerals offer interesting alternatives for use as drug-delivery systems. In the present study, new bionanocomposite drug-release systems were prepared from the intercalation of the antibiotic drug ciprofloxacin into montmorillonite using an ion-exchange reaction. In order to prepare more stable systems for oral ciprofloxacin release, this ciprofloxacin-clay intercalation compound was incorporated into i-carrageenan-gelatin biopolymer blend to produce bionanocomposite materials. Bionanocomposites of two distinct i-carrageenan and gelatin mass ratios were conformed as beads through an ionic gelification reaction with Ca²⁺ ions, and dried by freeze-drying where liquid nitrogen or conventional freezing was adopted in the freezing step. The resulting ciprofloxacin-clay hybrid was characterized by X-ray diffraction (XRD) analysis, Fourier-transform infrared (FTIR) spectroscopy, solid state ¹³C Nuclear Magnetic Resonance (NMR), thermal analysis, and scanning electron microscopy (SEM). The montmorillonite-ciprofloxacin hybrid incorporated into the bionanocomposite beads was evaluated by in vitro release studies which showed a significant difference in the release profiles in the aqueous medium used to simulate the gastrointestinal tract, depending on the blend composition and the freezing method employed in the preparation of the beads. The results point to bionanocomposite systems based on ciprofloxacin-clay hybrids and biopolymers that may be used as devices in the biomedical area.

控制药物释放系统的研究数量不断增加。可以由生物聚合物与无机固体（如粘土矿物）的组合制备的生物纳米复合材料为用作药物递送系统提供了有趣的替代品。在本研究中，使用离子交换反应将抗生素药物环丙沙星嵌入蒙脱石中制备了新的生物纳米复合药物释放系统。为了制备更稳定的口服环丙沙星释放系统，将这种环丙沙星-粘土插层化合物掺入异角叉菜胶-明胶生物聚合物混合物中以生产生物纳米复合材料。^{通过与 Ca 2+}的离子凝胶化反应，两种不同 i-角叉菜胶和明胶质量比的 Bionano 复合材料被整合为珠子离子，并通过冷冻干燥，冷冻步骤中采用液氮或常规冷冻。所得环丙沙星-粘土杂化物通过 X 射线衍射 (XRD) 分析、傅里叶变换红外 (FTIR) 光谱、固态^{13进行表征}C 核磁共振 (NMR)、热分析和扫描电子显微镜 (SEM)。通过体外释放研究评估了掺入生物纳米复合珠粒中的蒙脱石-环丙沙星杂化物，该研究显示在用于模拟胃肠道的水性介质中的释放曲线存在显着差异，具体取决于混合物组成和制备中采用的冷冻方法的珠子。结果表明基于环丙沙星-粘土混合物和生物聚合物的生物纳米复合系统可用作生物医学领域的设备。