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Quantified integrated hepatitis B virus is related to viral activity in patients with chronic hepatitis B
Hepatology ( IF 12.9 ) Pub Date : 2022-01-24 , DOI: 10.1002/hep.32352
Robin Erken 1, 2 , Vladimir Loukachov 1 , Karel van Dort 1 , Anne van den Hurk 1 , R Bart Takkenberg 2 , Anniki de Niet 2 , Louis Jansen 2 , Sophie Willemse 2 , Henk Reesink 3 , Neeltje Kootstra 1
Affiliation  

HBV can integrate in the host genome of the hepatocyte and recent findings suggest that integrated HBV contributes to the persistent production of viral proteins. Here, we quantified the levels of integrated HBV in patients with chronic hepatitis B (CHB) and analyzed the relation between HBV integration, virological activity (plasma HBV DNA and HBsAg levels), and clinical outcomes.

中文翻译:

定量的综合乙型肝炎病毒与慢性乙型肝炎患者的病毒活性有关

HBV 可以整合到肝细胞的宿主基因组中,最近的研究结果表明,整合的 HBV 有助于病毒蛋白的持续产生。在这里,我们量化了慢性乙型肝炎 (CHB) 患者的综合 HBV 水平,并分析了 HBV 整合、病毒学活性(血浆 HBV DNA 和 HBsAg 水平)和临床结果之间的关系。
更新日期:2022-01-24
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