Open-source projects continue to grow in popularity alongside open-source educational resources, software, and hardware tools. The impact of this increased availability of open-source technologies is that end users are empowered to have greater control over the tools that they work with. This trend extends in the life science laboratory space, where new open-source projects are routinely being published that allow users to build and modify scientific equipment specifically tailored to their needs, often at a reduced cost from equivalent commercial offerings. Recently, we identified a need for a compact orbital shaker that would be usable in temperature and humidity-controlled incubators to support the development and execution of a high-throughput suspension cell-based assay. Based on the requirements provided by staff biologists, an open-source project known as the DIYbio orbital shaker was identified on Thingiverse, then quickly prototyped and tested. The initial orbital shaker prototype based on the DIYbio design underwent an iterative prototyping and design process that proved to be straightforward due to the open-source nature of the project. The result of these efforts has been the successful initial deployment of ten shakers as of August 2021. This afforded us the scalability and efficacy needed to complete a large-scale screening campaign in less time and at less cost than if we purchased larger, less adaptable orbital shakers. Lessons learned from prototyping, modifying, validating, deploying and maintaining laboratory devices based on an open-source design in support of a full-scale drug discovery high-throughput screening effort are described within this manuscript.

中文翻译：

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快速部署廉价的开源轨道振荡器以支持高通量筛选。

开源项目与开源教育资源、软件和硬件工具一起继续流行。开源技术可用性增加的影响是最终用户有权更好地控制他们使用的工具。这种趋势延伸到生命科学实验室领域，新的开源项目定期发布，允许用户构建和修改专门针对其需求的科学设备，通常以低于同等商业产品的成本。最近，我们发现需要一种紧凑型轨道振荡器，该振荡器可用于温度和湿度控制的培养箱，以支持基于悬浮细胞的高通量检测的开发和执行。根据工作人员生物学家提供的要求，在 Thingiverse 上发现了一个名为 DIYbio 轨道振动器的开源项目，然后快速进行原型设计和测试。基于 DIYbio 设计的初始轨道振动台原型经历了迭代的原型设计和设计过程，由于该项目的开源性质，该过程被证明是简单的。这些努力的结果是，截至 2021 年 8 月，十台摇床已成功初始部署。与我们购买更大、适应性较差的情况相比，这为我们提供了在更短的时间内以更低的成本完成大规模筛选活动所需的可扩展性和有效性轨道振动器。从原型设计、修改、验证中吸取的经验教训，