Radiotherapy is one of the main cancer treatments, but it may damage normal tissue and cause various side effects. At present, radioprotective agents used in clinics have side effects such as nausea, vomiting, diarrhea and hypotension, which limit their clinical application. It has been found that exosomes play an indispensable role in radiation injury. Exosomes are lipid bilayer vesicles that carry various bioactive substances, such as proteins, lipids and microRNA (miRNA), that play a key role in cell-to-cell communication and affect tissue injury and repair. In addition, studies have shown that radiation can increase the uptake of exosomes in cells and affect the composition and secretion of exosomes. Here, we review the existing studies and discuss the effects of radiation on exosomes and the role of exosomes in radiation injury, aiming to provide new insights for the treatment of radiation injury.

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外泌体在放射损伤治疗中的治疗意义


放射治疗是主要的癌症治疗方法之一，但它可能会损害正常组织并引起各种副作用。目前临床使用的放射防护剂存在恶心、呕吐、腹泻、低血压等副作用，限制了其临床应用。研究发现外泌体在辐射损伤中发挥着不可或缺的作用。外泌体是脂质双层囊泡，携带各种生物活性物质，如蛋白质、脂质和微小RNA (miRNA)，在细胞间通讯中发挥关键作用，影响组织损伤和修复。此外，研究表明，辐射可以增加细胞对外泌体的摄取，并影响外泌体的组成和分泌。在此，我们回顾现有研究，讨论放射线对外泌体的影响以及外泌体在放射损伤中的作用，旨在为放射损伤的治疗提供新的见解。