Chronic wounds are defined as wounds that fail to proceed through the normal phases of wound healing in an orderly and timely manner. The most common and inevitable impairment to wound healing is the installation of an infection, usually in the case of chronic wounds. Therefore, the objective of the present review was to identify the importance of copper nanoparticles in dressings for wound healing. Nanoparticles such as silver, gold and copper combat infectious processes through the inhibition of protein synthesis, peroxidation of the cell membrane and destroying the nucleic acids of bacteria and viruses. Among bioactive nanoparticles, copper plays a complex role in various cells, it modulates several cytokines and growth factor mechanisms of action and is essentially involved in all stages of the wound healing process. More importantly, copper plays a key role in skin regeneration and angiogenesis and accelerates the healing process through induction of vascular endothelial growth factor (VEGF) and angiogenesis by hypoxia-induced factor-1-alpha (HIF-1α) action where copper enhances HIF-1α expression and HIF-1α binding to the critical motifs in the promoter and putative enhancer regions of HIF-1-regulated genes.

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铜纳米粒子在慢性伤口愈合中的作用：文献综述

慢性伤口的定义是伤口不能以有序和及时的方式进行正常的伤口愈合阶段。伤口愈合最常见和不可避免的损害是感染的安装，通常是在慢性伤口的情况下。因此，本综述的目的是确定铜纳米粒子在伤口愈合敷料中的重要性。银、金和铜等纳米颗粒通过抑制蛋白质合成、细胞膜过氧化以及破坏细菌和病毒的核酸来对抗感染过程。在生物活性纳米粒子中，铜在各种细胞中发挥着复杂的作用，它调节多种细胞因子和生长因子的作用机制，并且基本上参与了伤口愈合过程的所有阶段。更重要的是，