Even below the 99th percentile upper reference limit (99PURL), elevated high-sensitive cardiac troponin concentration (hs-cTn) is associated with increased cardiovascular risk [1]. However, the lower the troponin concentration, the higher the analytical imprecision [2]. It is unclear to what extent a change in hs-cTn (hs-cTn) is significant between the limit of detection (LOD) and the 99PURL. Recently, Lui et al. [3] compared, through a randomised control trial, the effect of 8 weeks of continuous positive airway pressure (CPAP) on hs-cTnI in subjects with moderate-to-severe obstructive sleep apnoea (OSA) and hypertension. They showed a statistically significant variation compared to untreated subjects (adjusted mean difference –1.74 ng·L^–1; p=0.006).

即使低于第 99 个百分位参考上限 (99PURL)，高敏心肌肌钙蛋白浓度 (hs-cTn) 升高也与心血管风险增加相关 [1]。然而，肌钙蛋白浓度越低，分析不精密度越高 [2]。目前尚不清楚 hs-cTn (hs-cTn) 的变化在检测限 (LOD) 和 99PURL 之间的显着程度。最近，L用户界面 等人。[3] 通过一项随机对照试验，比较了 8 周持续气道正压通气 (CPAP) 对中重度阻塞性睡眠呼吸暂停 (OSA) 和高血压患者 hs-cTnI 的影响。与未治疗的受试者相比，它们显示出统计学上的显着差异（调整后的平均差 –1.74 ng·L ^–1；p=0.006）。